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[嗜肺军团菌所致肺炎。在布宜诺斯艾利斯一家大学医院积累的经验]

[Pneumonia due to Legionella pneumophila. Experience gathered in a University Hospital in Buenos Aires].

作者信息

Luna Carlos M, Brea Folco Javier, Aruj Patricia, Rebora Karina, Balsebre Claudia, Absi Ruben, Vay Carlos, De Mier Carmen, Famiglietti Angela

机构信息

División Neumonología, Departamento de Medicina, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires.

出版信息

Medicina (B Aires). 2004;64(2):97-102.

Abstract

Legionnaires' disease is a well recognized cause of community acquired pneumonia (CAP) all around the world. In Latin America its incidence remains unknown. This study analyzed a cohort of 9 patients with CAP due to Legionella pneumophila observed from 1997 to 2001, in the Hospital de Clínicas José de San Martin, University of Buenos Aires. Clinical history included recent illnesses, work exposure, physical exam, prior antibiotic use and severity of illness criteria. None of the 9 patients had a history of recent travels, and 4 of them required admission in intensive care unit (ICU). Seven patients had a cigarette smoking history, four of them also had COPD, and one patient had a non-Hodgkin lymphoma. This study confirms the low specificity of clinical and general laboratory criteria to predict this etiology. Legionella isolation is difficult, and serological testing allows retrospective diagnosis but takes several weeks, while urinary antigen test gives a bed-side diagnosis. When Legionella appears in isolated cases, as happens in Argentina, it should be necessary to have a high index of suspicion to successfully arrive at an etiological diagnosis. Legionella pneumophila is a pathogen causing CAP in our area. A surveillance should be established preferably focused on selected populations including severe CAP, immunocompromised hosts and patients with chronic obstructive pulmonary disease.

摘要

军团病是全球公认的社区获得性肺炎(CAP)病因。在拉丁美洲,其发病率尚不清楚。本研究分析了1997年至2001年在布宜诺斯艾利斯大学何塞·德·圣马丁临床医院观察到的9例因嗜肺军团菌导致的CAP患者队列。临床病史包括近期疾病、工作接触史、体格检查、既往抗生素使用情况以及疾病严重程度标准。9例患者均无近期旅行史,其中4例需要入住重症监护病房(ICU)。7例患者有吸烟史,4例还患有慢性阻塞性肺疾病(COPD),1例患有非霍奇金淋巴瘤。本研究证实了临床和常规实验室标准预测该病因的低特异性。军团菌分离困难,血清学检测可进行回顾性诊断,但需要数周时间,而尿抗原检测可进行床旁诊断。当军团菌以散发病例出现时,如在阿根廷发生的情况,需要高度怀疑才能成功做出病因诊断。嗜肺军团菌是我们地区导致CAP的病原体。应建立监测,最好针对特定人群,包括重症CAP、免疫功能低下宿主和慢性阻塞性肺疾病患者。

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