不同药理制剂对大鼠皮瓣存活影响的比较研究

A comparative study on the effect of various pharmacological agents on the survival of skin flaps in the rat.

作者信息

Suárez Nieto C, Suárez García M J, Barthe García P

机构信息

Department of Otorhinolaryngology, Hospital Covadonga, University of Oviedo, Spain.

出版信息

Br J Plast Surg. 1992 Feb-Mar;45(2):113-6. doi: 10.1016/0007-1226(92)90169-x.

DOI:10.1016/0007-1226(92)90169-x

PMID:1562834

Abstract

The effects of chlorpromazine, pentoxifylline, terbutaline, allopurinol, phenoxybenzamine, naftidrofuryl, hydralazine and trimetazidine were investigated on caudally based dorsal flaps. The study was performed on 108 rats, divided in 9 groups of 12 animals each, one of which served as a control group. All treated groups showed a significantly greater survival of the flap than the control group. Comparisons among different groups showed better outcome in those receiving trimetazidine and hydralazine, followed by those receiving naftidrofuryl and phenoxybenzamine.

摘要

研究了氯丙嗪、己酮可可碱、特布他林、别嘌醇、酚苄明、萘呋胺酯、肼屈嗪和曲美他嗪对尾部蒂背侧皮瓣的影响。该研究在108只大鼠身上进行，分为9组，每组12只动物，其中一组作为对照组。所有治疗组的皮瓣存活率均显著高于对照组。不同组之间的比较显示，接受曲美他嗪和肼屈嗪的组效果更好，其次是接受萘呋胺酯和酚苄明的组。