[The value of patent-blue and transcutaneous pO2 in predicting the viability of skin flaps treated pharmacologically].

The effect of the patent-blue and the transcutaneous pO2 in the prediction of random flaps viability in the rat were studied. A control group of 12 rats and 8 study groups of 12 rats each were used. Different drugs were injected in the study groups: chlorpromazine, pentoxifylline, terbutaline, allopurinol, phenoxybenzamine, naftidrofuryl, hydralazine and trimetazidine. The stained area of the flap was significantly greater with pentoxifylline, phenoxybenzamine and trimetazidine. The surviving area was notably larger than the stained area, without any correlation between them. The preoperative values of pO2 showed a wide distribution, decreasing considerably in the immediate postoperative. After 48 hours pO2 values at least reached the preoperative levels. No correlation between pO2 measurements and the surviving area of the flap were observed.