Vranić Edina
Department of Pharmaceutical Technology, University of Sarajevo, Faculty of Pharmacy, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2004 Jul;4(3):35-9. doi: 10.17305/bjbms.2004.3383.
Amorphous forms are, by definition, non-crystalline materials which possess no long-range order. Their structure can be thought of as being similar to that of a frozen liquid with the thermal fluctuations present in a liquid frozen out, leaving only "static" structural disorder. The amorphous solids have always been an essential part of pharmaceutical research, but the current interest has been raised by two developments: a growing attention to pharmaceutical solids in general, especially polymorphs and solvates and a revived interest in the science of glasses and the glass transition. Amorphous substances may be formed both intentionally and unintentionally during normal pharmaceutical manufacturing operations. The properties of amorphous materials can be exploited to improve the performance of pharmaceutical dosage forms, but these properties can also give rise to unwanted effects that need to be understood and managed in order for the systems to perform as required.
根据定义，无定形形式是不具有长程有序性的非晶态材料。它们的结构可以被认为类似于冷冻液体，其中液体中的热涨落被冻结，只留下“静态”结构无序。无定形固体一直是药物研究的重要组成部分，但目前的兴趣是由两个发展引发的：对一般药物固体，特别是多晶型物和溶剂化物的日益关注，以及对玻璃科学和玻璃转变的重新关注。在正常的药物制造操作过程中，无定形物质可能有意无意地形成。无定形材料的特性可被利用来改善药物剂型的性能，但这些特性也可能产生不良影响，为使系统按要求运行，需要理解和控制这些影响。
