在系统层面分析生物学。

Analyzing the biology on the system level.

作者信息

Tong Wei

机构信息

Beijing Genomics Institute, Beijing 101300, China.

出版信息

Genomics Proteomics Bioinformatics. 2004 Feb;2(1):6-14. doi: 10.1016/s1672-0229(04)02002-9.

DOI:10.1016/s1672-0229(04)02002-9

PMID:15629038

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5172474/

Abstract

Although various genome projects have provided us enormous static sequence information, understanding of the sophisticated biology continues to require integrating the computational modeling, system analysis, technology development for experiments, and quantitative experiments all together to analyze the biology architecture on various levels, which is just the origin of systems biology subject. This review discusses the object, its characteristics, and research attentions in systems biology, and summarizes the analysis methods, experimental technologies, research developments, and so on in the four key fields of systems biology--systemic structures, dynamics, control methods, and design principles.

摘要

尽管各种基因组计划为我们提供了海量的静态序列信息，但要理解复杂的生物学仍需要将计算建模、系统分析、实验技术开发以及定量实验整合在一起，以便在各个层面分析生物学架构，而这正是系统生物学学科的起源。本文综述了系统生物学的研究对象、特点及研究关注点，并总结了系统生物学四个关键领域——系统结构、动力学、控制方法和设计原则——的分析方法、实验技术、研究进展等。