Jaskolski Frédéric, Coussen Françoise, Mulle Christophe
Laboratoire 'Physiologie Cellulaire de la Synapse', CNRS UMR 5091, Institut François Magendie, Université Bordeaux 2, rue C. Saint-Saëns, 33077 Bordeaux Cedex, France.
Trends Pharmacol Sci. 2005 Jan;26(1):20-6. doi: 10.1016/j.tips.2004.11.008.
Glutamate receptors of the kainate type have been identified recently as key players in the modulation of neuronal-network activity. The role of kainate receptors depends on their precise subcellular localization in presynaptic, postsynaptic and extrasynaptic domains. Subcellular localization of kainate receptors has been inferred mainly from electrophysiological studies with the help of selective pharmacological tools and kainate receptor mutant mice. These studies, combined with recent ultrastructural data, highlight the diversity of subcellular localizations of kainate receptors. It is important to understand the molecular mechanisms that underlie the polarized trafficking of kainate receptors in distinct neuronal domains. In this article, we review recent data that shed light on the trafficking and membrane delivery of kainate receptor isoforms, and on the identification of proteins that interact with kainate receptors and might regulate this trafficking.
近年来，已确定海人酸型谷氨酸受体是调节神经网络活动的关键因子。海人酸受体的作用取决于其在突触前、突触后和突触外区域精确的亚细胞定位。海人酸受体的亚细胞定位主要是借助选择性药理学工具和海人酸受体突变小鼠，通过电生理研究推断出来的。这些研究与最近的超微结构数据相结合，凸显了海人酸受体亚细胞定位的多样性。了解海人酸受体在不同神经元区域进行极化运输的分子机制很重要。在本文中，我们综述了最近的一些数据，这些数据揭示了海人酸受体亚型的运输和膜递送情况，以及与海人酸受体相互作用并可能调节这种运输的蛋白质的鉴定情况。
