Gray J R, Coldman A J, MacDonald W C
Cancer Agency, Vancouver, Canada.
Cancer. 1992 May 1;69(9):2227-31. doi: 10.1002/1097-0142(19920501)69:9<2227::aid-cncr2820690903>3.0.co;2-q.
The authors studied the cigarette and alcohol use of 243 patients with adenocarcinoma of the cardia or lower esophagus, including 66 with Barrett's metaplasia (esophagocardia group). They compared results of that investigation with the cigarette and alcohol use of 303 patients with squamous carcinoma of the esophagus, a cancer in which an etiologic association is proven, and of 338 patients with stomach cancer not involving the cardia, a cancer in which there is little or no association with cigarettes or alcohol. Controlled for other variables, patients with squamous cancer used more cigarettes and alcohol than the other two groups. There was no significant difference in cigarette or alcohol use between patients with esophagocardia and stomach cancer or between those in the esophagocardia group with or without Barrett's metaplasia. Because cigarette and alcohol use was not greater in patients with esophagocardia than in those with stomach cancer, the authors do not think that such factors explain the increasing incidence of adenocarcinoma of the cardia or lower esophagus.
作者研究了243例贲门或食管下段腺癌患者的吸烟和饮酒情况，其中66例伴有巴雷特化生（食管贲门组）。他们将该调查结果与303例食管鳞状细胞癌患者（一种病因关联已得到证实的癌症）以及338例非贲门部胃癌患者（一种与吸烟或饮酒几乎没有关联的癌症）的吸烟和饮酒情况进行了比较。在对其他变量进行控制后，食管鳞状细胞癌患者比其他两组使用更多的香烟和酒精。食管贲门癌患者与胃癌患者之间，以及食管贲门组中有或没有巴雷特化生的患者之间，在吸烟或饮酒方面没有显著差异。由于食管贲门癌患者的吸烟和饮酒情况并不比胃癌患者更严重，作者认为这些因素并不能解释贲门或食管下段腺癌发病率上升的原因。
