MacDonald W C, MacDonald J B
Cancer. 1987 Sep 1;60(5):1094-8. doi: 10.1002/1097-0142(19870901)60:5<1094::aid-cncr2820600529>3.0.co;2-4.
One hundred twenty-nine adenocarcinomas involving the esophagus and/or gastric cardia differed significantly from 212 cancers of the rest of the stomach as follows: male-female ratio, 6:1 versus 2:1, birth outside Canada, US or UK, 12% versus 34%; parent or sibling with gastric cancer, 5% versus 13%; previous duodenal ulcer, 23% versus 9%; chronic reflux symptoms, 25% versus 3%; hiatal hernia, 51% versus 11%. Of the 129 esophagocardia cancers, 24 involved the esophagus alone, 48 the cardia and esophagus, 33 the cardia alone or cardia and fundus, and 24 the upper stomach and lower esophagus extensively. Thirty-four were associated with Barrett's esophagus. The 72 patients with involvement of both the upper stomach and lower esophagus (48 cardia and esophagus, 24 extensive) were identical with the esophagocardia group as a whole. The 24 patients with esophageal cancer and the 34 with Barrett's epithelium were the same clinically as the whole esophagocardia group except more had chronic reflux and hiatal hernia. The 33 patients with cancer confined to the cardia or cardia and fundus resembled the whole esophagocardia group but did not have Barrett's esophagus. Adenocarcinoma of the esophagocardia region is probably a different disease from cancer of the rest of the stomach.
129例累及食管和/或胃贲门的腺癌与212例胃其他部位的癌症存在显著差异，具体如下：男女比例，分别为6:1和2:1；出生于加拿大、美国或英国以外地区，分别为12%和34%；父母或兄弟姐妹患有胃癌，分别为5%和13%；既往有十二指肠溃疡，分别为23%和9%；有慢性反流症状，分别为25%和3%；有食管裂孔疝，分别为51%和11%。在129例食管贲门癌中，24例仅累及食管，48例累及贲门和食管，33例仅累及贲门或累及贲门和胃底，24例广泛累及胃上部和食管下部。34例与巴雷特食管相关。72例胃上部和食管下部均受累的患者（48例贲门和食管，24例广泛受累）与整个食管贲门癌组情况相同。24例食管癌患者和34例有巴雷特上皮的患者在临床上与整个食管贲门癌组相同，只是更多患者有慢性反流和食管裂孔疝。33例癌症局限于贲门或贲门和胃底的患者与整个食管贲门癌组相似，但没有巴雷特食管。食管贲门区域的腺癌可能与胃其他部位的癌症是不同的疾病。
