Biesiada E, Krawczyk Z, Chorazy M
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Cell Biol Int Rep. 1992 Jan;16(1):53-62. doi: 10.1016/s0309-1651(06)80156-6.
In rat liver stimulated by partial hepatectomy a significant expression of Egr-1 and to less extent c-jun genes was observed within 15-30 min after the surgery. The induction is transient and vanishes within one hour. Egr-1 and c-jun were also induced in liver after subcutaneous injection of turpentine, a strong inducer of acute phase response. A maximum activation of these genes was observed within 4-9 hours after administration of turpentine. Both Egr-1 and c-jun extend the list of "immediate early" genes involved in proliferative response and constitute a group of genes inducible at the beginning of acute phase response.
在部分肝切除术后受到刺激的大鼠肝脏中，术后15 - 30分钟内观察到Egr - 1基因显著表达，c - jun基因表达程度较低。这种诱导是短暂的，1小时内就会消失。皮下注射松节油（一种急性期反应的强诱导剂）后，肝脏中也会诱导Egr - 1和c - jun基因表达。注射松节油后4 - 9小时观察到这些基因的最大激活。Egr - 1和c - jun都扩展了参与增殖反应的“立即早期”基因列表，并构成了一组在急性期反应开始时可诱导的基因。
