Bernuau D, Rogier E, Moreau A, Bernuau J, Feldmann G
Gastroenterology. 1986 Feb;90(2):268-73. doi: 10.1016/0016-5085(86)90920-0.
We evaluated the influence of an acute inflammatory reaction that triggers the synthesis of exportable proteins by hepatocytes on liver regeneration after partial hepatectomy, which induces the synthesis of proteins necessary for liver cell proliferation. In hepatectomized rats with a turpentine-induced acute inflammatory reaction, the first peaks of hepatic DNA synthesis and mitosis were significantly inhibited compared with pair-fed controls subjected to partial hepatectomy only, and the liver DNA concentration at various times after partial hepatectomy was significantly lower in the former than in the latter. Inhibition was not obtained when the acute inflammatory reaction was induced 12 h or more before partial hepatectomy, suggesting that the inhibitory effect of turpentine administration depended on early events in the acute inflammatory reaction. These data suggest that one possible mechanism responsible for inhibition of regeneration might be competition at the transcriptional or the translational level between liver syntheses of various proteins, and that, under certain conditions, liver-specific functions might take precedence over regenerative functions.
我们评估了由肝细胞触发可输出蛋白合成的急性炎症反应对部分肝切除术后肝脏再生的影响，部分肝切除术可诱导肝细胞增殖所需蛋白质的合成。在因松节油诱导急性炎症反应而接受肝切除术的大鼠中，与仅接受部分肝切除术的配对喂养对照组相比，肝脏DNA合成和有丝分裂的首个峰值受到显著抑制，并且在部分肝切除术后不同时间点，前者的肝脏DNA浓度显著低于后者。当在部分肝切除术前12小时或更长时间诱导急性炎症反应时，未观察到抑制作用，这表明松节油给药的抑制作用取决于急性炎症反应的早期事件。这些数据表明，抑制再生的一种可能机制可能是各种蛋白质在肝脏合成过程中在转录或翻译水平上的竞争，并且在某些条件下，肝脏特异性功能可能优先于再生功能。
