用于特发性突发性感音神经性听力损失的口服类固醇治疗方案。
Oral steroid regimens for idiopathic sudden sensorineural hearing loss.
作者信息
Slattery William H, Fisher Laurel M, Iqbal Zarina, Liu Nancy
机构信息
House Ear Institute, Los Angeles, CA 90057, USA.
出版信息
Otolaryngol Head Neck Surg. 2005 Jan;132(1):5-10. doi: 10.1016/j.otohns.2004.09.072.
OBJECTIVE
To determine hearing recovery in patients with idiopathic sudden hearing loss treated with varying amounts of oral steroids.
STUDY DESIGN AND SETTING
A retrospective chart review (n = 75) in a tertiary care clinic examined sudden hearing loss patients treated with 1 60-mg prednisone taper, 1 course of steroid less than a 60-mg taper, or any 2 courses of oral steroid.
RESULTS
Overall, 35% of the patients recovered a clinically significant amount of hearing. Recovery was associated with immediate treatment (within 2 weeks from onset), better hearing at the onset of treatment, and treatment with the higher dose of prednisone in patients with just 1 additional symptom (dizziness or tinnitus). Patients tended to continue to experience some recovery in hearing up to 4 months after treatment.
CONCLUSION
Immediate treatment of patients with unilateral idiopathic sudden hearing loss and additional symptoms (dizziness or tinnitus) with a 14-day course of 60 mg prednisone (with taper) is recommended.
EBM RATING
B-3.
目的
确定接受不同剂量口服类固醇治疗的特发性突发性感音神经性听力损失患者的听力恢复情况。
研究设计与背景
在一家三级护理诊所进行的一项回顾性病历审查（n = 75），研究对象为接受以下治疗的突发性感音神经性听力损失患者：1次60毫克泼尼松逐渐减量治疗、1个疗程低于60毫克逐渐减量的类固醇治疗或任何2个疗程的口服类固醇治疗。
结果
总体而言，35%的患者听力恢复到具有临床意义的程度。听力恢复与立即治疗（发病后2周内）、治疗开始时听力较好以及仅有1种额外症状（头晕或耳鸣）的患者接受更高剂量泼尼松治疗有关。患者在治疗后长达4个月内往往仍会继续出现一定程度的听力恢复。
结论
建议对单侧特发性突发性感音神经性听力损失且伴有额外症状（头晕或耳鸣）的患者，采用60毫克泼尼松（逐渐减量）进行为期14天的治疗。
循证医学评级
B - 3
Zotero 插件