糖皮质激素对特发性突发性聋预后的影响。
Glucocorticoid influence on prognosis of idiopathic sudden sensorineural hearing loss.
机构信息
Department of Otorhinolaryngology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
出版信息
Braz J Otorhinolaryngol. 2014 May-Jun;80(3):213-9. doi: 10.1016/j.bjorl.2014.02.002.
INTRODUCTION
Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) is defined when a loss of at least 30 dB occurs in over 3 continuous frequencies, in up to 72 hours, of which etiology is not established, despite adequate investigation. Different types of treatment regimens have been proposed, but only glucocorticoids have shown some evidence of benefit in the literature.
OBJECTIVE
To analyze whether the type of treatment or time of treatment with glucocorticoids have any influence on hearing recovery in ISSHL.
METHODS
Observational retrospective cohort study. One hundred twenty-seven patients with ISSHL, treated at outpatient clinics between the years 2000 and 2010, were studied. We evaluated the prognostic correlation of the type of treatment and time to treatment with glucocorticoids and ISSHL.
RESULTS
The absolute hearing gain and the relative hearing gain was as follows: 23.6 dB and 37.2%. Complete recovery was observed in 15.7% of patients, significant recovery in 27.6% and recovery in 57.5%.
CONCLUSION
In this study, there was no difference between the use and nonuse of glucocorticoids in hearing improvement. However, when started within seven days after onset, the use of glucocorticoids was a factor of better prognosis.
简介
特发性突发性聋（ISSHL）是指在 72 小时内，至少有 3 个连续频率出现 30dB 以上的听力损失，且病因不明，尽管进行了充分的检查。已经提出了不同类型的治疗方案，但只有糖皮质激素在文献中显示出一些获益的证据。
目的
分析糖皮质激素的治疗类型或治疗时间是否对 ISSHL 的听力恢复有影响。
方法
观察性回顾性队列研究。研究了 2000 年至 2010 年间在门诊接受治疗的 127 例 ISSHL 患者。我们评估了治疗类型和糖皮质激素治疗时间与 ISSHL 的预后相关性。
结果
绝对听力增益和相对听力增益分别为 23.6dB 和 37.2%。15.7%的患者完全恢复，27.6%的患者显著恢复，57.5%的患者恢复。
结论
在这项研究中，使用和不使用糖皮质激素在听力改善方面没有差异。然而，在发病后 7 天内开始使用糖皮质激素是预后较好的一个因素。
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