Kearney John F
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294-3300, USA.
Springer Semin Immunopathol. 2005 Mar;26(4):377-83. doi: 10.1007/s00281-004-0184-0. Epub 2005 Jan 12.
Numerous studies in several species have shown that certain subsets of T and B lymphocytes express antigen receptors which are either semi-invariant, or germline encoded, and often autoreactive. In the case of B cells they appear to use a distinct immune recognition strategy during developmental selection and functional activation. These B cells respond to foreign antigens, and have the ability to protect against a variety of infections; however, they can also react with self or neoself antigens. They appear to use the latter as positively selecting ligands facilitating their entry into and maintenance in a functional repertoire, as well as providing cues for positioning themselves in strategic microenvironmental niches in the immune system and at interfaces with the environment. These innate-like B cell subsets form a bridge between the rapidly occurring innate immune responses, and the slower acting primary, T cell-dependent, adaptive antibody response by providing a rapid T cell-independent antibody response.
对多个物种的大量研究表明，T淋巴细胞和B淋巴细胞的某些亚群表达半不变或种系编码的抗原受体，且这些受体通常具有自身反应性。就B细胞而言，它们在发育选择和功能激活过程中似乎采用了独特的免疫识别策略。这些B细胞对外源抗原作出反应，具有抵御多种感染的能力；然而，它们也能与自身或新自身抗原发生反应。它们似乎将后者用作阳性选择配体，促进其进入功能性库并维持在该库中，同时为它们在免疫系统中以及与环境的界面处的战略微环境龛中定位提供线索。这些类天然B细胞亚群通过提供快速的非T细胞依赖性抗体反应，在快速发生的天然免疫反应和作用较慢的主要的、T细胞依赖性的适应性抗体反应之间架起了一座桥梁。
