• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Cytotoxicity of epigallocatechin-3-gallate to LNCaP cells in the presence of Cu2+.表没食子儿茶素没食子酸酯在Cu2+存在下对LNCaP细胞的细胞毒性。
J Zhejiang Univ Sci B. 2005 Feb;6(2):125-31. doi: 10.1631/jzus.2005.B0125.
2
Investigations of the cytotoxicity of epigallocatechin-3-gallate against PC-3 cells in the presence of Cd2+ in vitro.表没食子儿茶素没食子酸酯在体外Cd2+存在下对PC-3细胞的细胞毒性研究。
Toxicol In Vitro. 2008 Jun;22(4):953-60. doi: 10.1016/j.tiv.2008.02.005. Epub 2008 Feb 15.
3
Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.绿茶多酚及其成分表没食子儿茶素没食子酸酯在体外和体内均能抑制人乳腺癌细胞的增殖。
Cancer Lett. 2007 Jan 8;245(1-2):232-41. doi: 10.1016/j.canlet.2006.01.027. Epub 2006 Mar 6.
4
Growth inhibition of prostate cancer cells by epigallocatechin gallate in the presence of Cu2+.表没食子儿茶素没食子酸酯在Cu2+存在下对前列腺癌细胞的生长抑制作用。
J Agric Food Chem. 2004 Feb 11;52(3):462-6. doi: 10.1021/jf035057u.
5
Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells.绿茶成分（-）-表没食子儿茶素-3-没食子酸酯对雄激素敏感和雄激素不敏感的人前列腺癌细胞的生长抑制、细胞周期失调及凋亡诱导作用
Toxicol Appl Pharmacol. 2000 Apr 1;164(1):82-90. doi: 10.1006/taap.1999.8885.
6
Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention.没食子酸表没食子儿茶素酯载多糖纳米粒用于前列腺癌化学预防。
Nanomedicine (Lond). 2011 Jan;6(1):79-87. doi: 10.2217/nnm.10.101.
7
Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis.绿茶多酚表没食子儿茶素没食子酸酯（EGCG）使人类前列腺癌LNCaP细胞对TRAIL介导的凋亡敏感，并协同抑制与血管生成和转移相关的生物标志物。
Oncogene. 2008 Mar 27;27(14):2055-63. doi: 10.1038/sj.onc.1210840. Epub 2007 Nov 12.
8
Anti-tumor effect of ascorbic acid, lysine, proline, arginine, and epigallocatechin gallate on prostate cancer cell lines PC-3, LNCaP, and DU145.抗坏血酸、赖氨酸、脯氨酸、精氨酸和表没食子儿茶素没食子酸酯对前列腺癌细胞系PC-3、LNCaP和DU145的抗肿瘤作用。
Res Commun Mol Pathol Pharmacol. 2004;115-116:251-64.
9
The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells.绿茶多酚表没食子儿茶素没食子酸酯可抑制耐药肺癌细胞中的端粒酶并诱导其凋亡。
Biochem Biophys Res Commun. 2007 Aug 17;360(1):233-7. doi: 10.1016/j.bbrc.2007.06.030. Epub 2007 Jun 14.
10
Epigallocatechin-3-gallate affects the growth of LNCaP cells via membrane fluidity and distribution of cellular zinc.表没食子儿茶素-3-没食子酸酯通过膜流动性和细胞锌分布影响LNCaP细胞的生长。
J Zhejiang Univ Sci B. 2009 Jun;10(6):411-21. doi: 10.1631/jzus.B0820400.

引用本文的文献

1
Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer.防治前列腺癌的必需元素和异黄酮。
Nutrients. 2022 Mar 14;14(6):1225. doi: 10.3390/nu14061225.
2
Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).柳叶菜（火草）中多酚的治疗潜力
Phytother Res. 2016 Aug;30(8):1287-97. doi: 10.1002/ptr.5648. Epub 2016 May 24.
3
Epigallocatechin-3-gallate and zinc provide anti-apoptotic protection against hypoxia/reoxygenation injury in H9c2 rat cardiac myoblast cells.表没食子儿茶素-3-没食子酸酯和锌对H9c2大鼠心肌成肌细胞缺氧/复氧损伤具有抗凋亡保护作用。
Mol Med Rep. 2015 Aug;12(2):1850-6. doi: 10.3892/mmr.2015.3603. Epub 2015 Apr 8.
4
Epigallocatechin-3-gallate affects the growth of LNCaP cells via membrane fluidity and distribution of cellular zinc.表没食子儿茶素-3-没食子酸酯通过膜流动性和细胞锌分布影响LNCaP细胞的生长。
J Zhejiang Univ Sci B. 2009 Jun;10(6):411-21. doi: 10.1631/jzus.B0820400.

本文引用的文献

1
Growth inhibition of prostate cancer cells by epigallocatechin gallate in the presence of Cu2+.表没食子儿茶素没食子酸酯在Cu2+存在下对前列腺癌细胞的生长抑制作用。
J Agric Food Chem. 2004 Feb 11;52(3):462-6. doi: 10.1021/jf035057u.
2
Size exclusion chromatographic analysis of polyphenol-serum albumin complexes.多酚 - 血清白蛋白复合物的尺寸排阻色谱分析
Phytochemistry. 2003 Aug;63(7):817-23. doi: 10.1016/s0031-9422(03)00340-6.
3
Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol.表没食子儿茶素没食子酸酯的抗致突变、抗基因毒性及凋亡活性：一种绿茶多酚
Mutat Res. 2003 Feb-Mar;523-524:33-41. doi: 10.1016/s0027-5107(02)00319-6.
4
Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity.黄酮类化合物与铁离子和铜离子的相互作用：其抗氧化活性的一种机制
Free Radic Res. 2002 Nov;36(11):1199-208. doi: 10.1080/1071576021000016463.
5
Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells.（-）-表没食子儿茶素-3-没食子酸酯诱导人前列腺癌细胞细胞周期阻滞和凋亡的分子途径。
Arch Biochem Biophys. 2003 Feb 1;410(1):177-85. doi: 10.1016/s0003-9861(02)00668-9.
6
Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways.茶多酚通过调节信号转导通路实现癌症化学预防。
Arch Pharm Res. 2002 Oct;25(5):561-71. doi: 10.1007/BF02976924.
7
Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice.局部应用咖啡因或（-）-表没食子儿茶素没食子酸酯（EGCG）可抑制致癌作用，并选择性地增加小鼠紫外线B诱导的皮肤肿瘤中的细胞凋亡。
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12455-60. doi: 10.1073/pnas.182429899. Epub 2002 Aug 30.
8
Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.多酚对人5α-还原酶抑制作用的构效关系
Biochem Pharmacol. 2002 Mar 15;63(6):1165-76. doi: 10.1016/s0006-2952(02)00848-1.
9
Spin-trapping study on the hydroxyl radical formed from a tea catechin-Cu(II) system.茶儿茶素 - 铜（II）体系产生的羟基自由基的自旋捕集研究
Biosci Biotechnol Biochem. 2001 Aug;65(8):1697-706. doi: 10.1271/bbb.65.1697.
10
Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate.茶多酚（-）-表没食子儿茶素-3-没食子酸酯和茶黄素-3,3'-二没食子酸酯对30.7b Ras 12细胞中Ras-MAP激酶信号通路的抑制机制。
FASEB J. 2001 Sep;15(11):2022-4. doi: 10.1096/fj.01-0031fje. Epub 2001 Jul 9.

表没食子儿茶素没食子酸酯在Cu2+存在下对LNCaP细胞的细胞毒性。

Cytotoxicity of epigallocatechin-3-gallate to LNCaP cells in the presence of Cu2+.

作者信息

Yu Hai-ning, Shen Sheng-rong, Xiong Yao-kang

机构信息

Department of Tea Science, School of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310009, China.

出版信息

J Zhejiang Univ Sci B. 2005 Feb;6(2):125-31. doi: 10.1631/jzus.2005.B0125.

DOI:10.1631/jzus.2005.B0125
PMID:15633248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1389627/
Abstract

Epigallocatechin-3-gallate (EGCG) has shown remarkably anti-cancer activity, with its bioactivity being related to reactive conditions, such as pH and metal ions. The present study investigated the degradation of EGCG and its effect on prostate cancer cell in the presence of Cu2+. EGCG was incubated with prostate cancer cells, LNCaP, pretreated with or without Cu2+. EGCG in F-12 medium was quantified using HPLC and the viability of cells was assessed by gel electrophoresis, flow cytometry, and electron microscope. The results of HPLC showed that EGCG degraded completely within 12 h in F-12 medium with or without Cu2+. Gel electrophoresis and flow cytometry did not detect apoptosis of LNCaP cells when they were incubated with EGCG. Electron microscopy examination revealed that EGCG-Cu2+ complex led to damage of cytoplasm membrane in LNCaP cells. It was speculated that not EGCG, but its oxide and complex with Cu2+, are the bioactive components responsible for its cytotoxicity to LNCaP prostate cancer cells.

摘要

表没食子儿茶素-3-没食子酸酯（EGCG）已显示出显著的抗癌活性，其生物活性与反应条件有关，如pH值和金属离子。本研究调查了在Cu2+存在下EGCG的降解及其对前列腺癌细胞的影响。将EGCG与经或未经Cu2+预处理的前列腺癌细胞LNCaP一起孵育。使用高效液相色谱法（HPLC）对F-12培养基中的EGCG进行定量，并通过凝胶电泳、流式细胞术和电子显微镜评估细胞活力。HPLC结果表明，无论有无Cu2+，EGCG在F-12培养基中12小时内完全降解。当LNCaP细胞与EGCG孵育时，凝胶电泳和流式细胞术未检测到细胞凋亡。电子显微镜检查显示，EGCG-Cu2+复合物导致LNCaP细胞的细胞质膜损伤。据推测，对LNCaP前列腺癌细胞具有细胞毒性的生物活性成分不是EGCG，而是其氧化物以及与Cu2+形成的复合物。