放线菌酮和放线菌素D对植物血凝素激活的人淋巴细胞中酸性核蛋白产生的影响。
Effects of cycloheximide and actinomycin D on production of acidic nuclear proteins in human lymphocytes activated by phytohemagglutinin.
作者信息
Dekio S
机构信息
Department of Dermatology, Hiroshima Hospital of Japanese National Railways, Futabanosato 3-1-36, Hiroshima, Japan.
出版信息
J Dermatol. 1976 Aug;3(4):159-62. doi: 10.1111/j.1346-8138.1976.tb01837.x.
Abstract
Previous studies have implicated a role for acidic nuclear proteins in the PHA stimulated activation of human lymphocytes. This study examines the mechanism of synthesis of these proteins. Cycloheximide inhibited their production, while Actinomycin D did not. It is suggested that synthesis proceeds by translation of dormant messenger RNA rather than of newly synthesized messenger RNA.
摘要
先前的研究表明酸性核蛋白在植物血凝素刺激的人淋巴细胞活化过程中发挥作用。本研究探讨了这些蛋白的合成机制。放线菌酮抑制它们的产生，而放线菌素D则不然。研究表明，合成是通过翻译休眠信使核糖核酸而非新合成的信使核糖核酸进行的。
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