Peters-Golden Marc, Canetti Claudio, Mancuso Peter, Coffey Michael J
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor 48109, USA.
J Immunol. 2005 Jan 15;174(2):589-94. doi: 10.4049/jimmunol.174.2.589.
Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by resident and recruited leukocytes during infection. Acting via cell surface G protein-coupled receptors and subsequent intracellular signaling events, they enhance leukocyte accumulation, phagocyte capacity for microbial ingestion and killing, and generation of other proinflammatory mediators. Interestingly, a variety of acquired states of immunodeficiency, such as HIV infection and malnutrition, are characterized by a relative deficiency of leukotriene synthesis. The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity.
白三烯是支气管收缩剂和血管活性脂质介质，是哮喘治疗的靶点。尽管它们越来越被认为具有广泛的促炎作用，但其在先天免疫反应中的作用却鲜为人知。这些分子确实是在感染期间由驻留和募集的白细胞合成的。它们通过细胞表面G蛋白偶联受体及随后的细胞内信号转导事件发挥作用，增强白细胞聚集、吞噬细胞摄取和杀灭微生物的能力，以及其他促炎介质的产生。有趣的是，多种获得性免疫缺陷状态，如HIV感染和营养不良，其特征是白三烯合成相对不足。本文综述的数据表明，白三烯是先天免疫中未得到充分认识但高度相关的介质。
