Orhan Gani, Bayram Aysen, Zer Yasemin, Balci Iclal
Gaziantep University Medical Faculty, Department of Microbiology and Clinical Microbiology, Universite Bulvari, 27310 Gaziantep, Turkey.
J Clin Microbiol. 2005 Jan;43(1):140-3. doi: 10.1128/JCM.43.1.140-143.2005.
Two different synergy testing methods, the checkerboard and the E test methods, were used to compare the in vitro efficacies of various antimicrobial combinations against 16 Brucella melitensis strains isolated from blood cultures. The rate of agreement of the E test and checkerboard methods was found to be 55%. The most concordant results were found for the streptomycin-doxycycline combination in 12 (75%) tests, in which four strains showed synergistic activity by E test and antagonistic activity by the checkerboard method and in which one strain showed antagonistic activity by both methods. Even though each of these methods uses different conditions and endpoints, the results of both methods frequently agreed.
采用两种不同的协同试验方法，棋盘法和E试验法，比较了多种抗菌药物组合对从血培养中分离出的16株羊布鲁氏菌的体外抗菌效果。发现E试验法和棋盘法的一致率为55%。在12次（75%）试验中，链霉素-强力霉素组合的结果最为一致，其中4株菌通过E试验显示协同活性，通过棋盘法显示拮抗活性，1株菌在两种方法中均显示拮抗活性。尽管这两种方法采用了不同的条件和终点，但两种方法的结果经常一致。
