Mori Miwako
Department of Fine Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Yakugaku Zasshi. 2005 Jan;125(1):51-72. doi: 10.1248/yakushi.125.51.
Recently, many organometallic complexes, such as palladium, nickel, ruthenium, titanium complexes and others, were used for synthetic organic chemistry. We have developed many novel synthetic methods using these organometallic complexes for synthetic organic chemistry. As the organometallic complexes, nickel, chromium, molybdenum, ruthenium, zirconium, titanium, and palladium complexes, were used. Furthermore, bimetallic complexes having silicon-tin and silicon-zirconium bonds were investigated. On the other hand, utilization of gases in synthetic organic chemistry has been also developed. 1 atm pressure of gases such as CO, CO(2), N(2), ethylene and acetylene, could be used and the reaction procedure is very simple, that a balloon filled with a gas is connected on the top of the flask. Using our novel synthetic methods, we have synthesized many natural products and biologically active substances, such as cephalotaxin, mesembrine, tubifoline, strychnine, stemoamide, lycopodine, pumiliotoxin C, beta-lactam, carbapenam and benzodiazepinone derivatives.
最近，许多有机金属配合物，如钯、镍、钌、钛配合物等，被用于有机合成化学。我们已经开发了许多使用这些有机金属配合物进行有机合成化学的新方法。作为有机金属配合物，使用了镍、铬、钼、钌、锆、钛和钯配合物。此外，还研究了具有硅-锡和硅-锆键的双金属配合物。另一方面，有机合成化学中气体的利用也得到了发展。可以使用1个大气压的气体，如CO、CO₂、N₂、乙烯和乙炔，反应过程非常简单，即将充满气体的气球连接在烧瓶顶部。使用我们的新合成方法，我们已经合成了许多天然产物和生物活性物质，如三尖杉酯碱、美登木碱、 tubifoline、士的宁、stemoamide、石松碱、箭毒蛙毒素C、β-内酰胺、碳青霉烯和苯二氮卓酮衍生物。
