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低密度脂蛋白大小:这重要吗?

LDL size: does it matter?

作者信息

Berneis K, Rizzo M

机构信息

University Hospital Bruderholz, Department of Internal Medicine, Switzerland.

出版信息

Swiss Med Wkly. 2004 Dec 18;134(49-50):720-4. doi: 10.4414/smw.2004.10813.

DOI:10.4414/smw.2004.10813
PMID:15635490
Abstract

The atherogenic lipoprotein phenotype is characterised by a moderate increase in plasma triglycerides, a decrease in high density lipoprotein cholesterol and the prevalence of smaller denser low density lipoprotein particles. The prevalence of this partially inheritable phenotype is approximately 30% and is a feature of the metabolic syndrome associated with an increased risk for cardiovascular events. The predominance of small dense LDL has been accepted as an emerging cardiovascular risk factor by the adult treatment panel (ATP) III.

摘要

致动脉粥样硬化脂蛋白表型的特征是血浆甘油三酯适度升高、高密度脂蛋白胆固醇降低以及较小且密度较高的低密度脂蛋白颗粒占优势。这种部分可遗传表型的患病率约为30%,是代谢综合征的一个特征,与心血管事件风险增加相关。小而密低密度脂蛋白的优势已被成人治疗小组(ATP)III认定为一种新出现的心血管危险因素。

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