Van Raemdonck Dirk E M, Rega Filip R, Neyrinck Arne P, Jannis Nicole, Verleden Geert M, Lerut Toni E
Thoracic Surgical Research Unit, Center for Experimental Surgery and Anaesthesiology, Catholic University, Leuven, Belgium.
Semin Thorac Cardiovasc Surg. 2004 Winter;16(4):309-21. doi: 10.1053/j.semtcvs.2004.09.014.
The widespread application of lung transplantation is limited by the shortage of suitable donor organs resulting in longer waiting times for listed patients with a substantial risk of dying before transplantation. To overcome this critical organ shortage, some transplant programs have now begun to explore the use of lungs from circulation-arrested donors, so called non-heart-beating donors (NHBDs). This review outlines the different categories of NHBDs, the relevant published experimental data that support the use of lungs coming from these donors and the clinical experience worldwide so far. Techniques for NHBD lung preservation and pretransplant functional assessment are reviewed. Ethical issues involved in transplanting lungs from asystolic donors are discussed.
肺移植的广泛应用受到合适供体器官短缺的限制，这导致登记在册的患者等待时间延长，他们在移植前有很高的死亡风险。为了克服这种严重的器官短缺问题，一些移植项目现已开始探索使用来自循环停止供体的肺，即所谓的非心脏跳动供体（NHBD）。本综述概述了NHBD的不同类别、支持使用这些供体的肺的相关已发表实验数据以及迄今为止全球的临床经验。还对NHBD肺保存技术和移植前功能评估进行了综述。讨论了移植来自心脏停搏供体的肺所涉及的伦理问题。
