Macák J, Plank L, Habanec B, Fabián P, Curík R, Nieslanik J, Bobot L, Vácha P, Utíkal Z, Dvorácková J
Ustav patologie Lékarské fakulty UP, Olomouc.
Vnitr Lek. 2000 Jul;46(7):387-90.
The number of EBV-positive child patients with HL varies in different countries and regions. In developing countries the number of child patients with this disease is higher than in the patient population of economically advanced countries. The authors examined 24 patients under 10 years with Hodgkin's lymphoma. Twenty patients were males, four females. In ten cases according to histological examination type II of HL was involved--nodular sclerosis (7 boys, 3 girls). In 14 instances the authors detected the mixed cellularity type (13 boys and 1 girl). EBV positivity was assessed immunohistologically by means of the antibody against LMP-1 and EBER-1 by the method of in situ hybridization. In 20 EBV positive HL 18 boys and 2 girls were affected. EBV positivity was proved in 83%. The marked intersexual difference in different EBV positive HL has not been explained unequivocally so far. The authors proved, that 14 EBV positive HL were type III--mixed cellularity. In 6 cases the type of nodular sclerosis was involved. The authors assume that marked positivity of child patients is associated with the initial massive EBV infection. EBV positive tumour cells are to a considerable extent removed by the immune apparatus and thus in the second and third decade EBV negative patients predominate.
EBV阳性的儿童霍奇金淋巴瘤（HL）患者数量在不同国家和地区有所不同。在发展中国家，这种疾病的儿童患者数量高于经济发达国家的患者群体。作者检查了24例10岁以下的霍奇金淋巴瘤患者。其中20例为男性，4例为女性。根据组织学检查，10例患者为II型HL——结节硬化型（7名男孩，3名女孩）。14例患者为混合细胞型（13名男孩和1名女孩）。通过免疫组织化学方法，使用抗LMP-1抗体和原位杂交法检测EBER-1来评估EBV阳性情况。在20例EBV阳性的HL患者中，18例为男孩，2例为女孩。EBV阳性率为83%。到目前为止，不同EBV阳性HL中明显的两性差异尚未得到明确解释。作者证实，14例EBV阳性的HL为III型——混合细胞型。6例为结节硬化型。作者认为，儿童患者的高阳性率与最初的大量EBV感染有关。EBV阳性肿瘤细胞在很大程度上被免疫系统清除，因此在第二和第三个十年中，EBV阴性患者占主导。
