Hasanjani Roushan M R, Mohrez M, Smailnejad Gangi S M, Soleimani Amiri M J, Hajiahmadi M
Department of Infectious Diseases, Yahyanejad Hospital, Babol Medical University, Babol, Iran.
Epidemiol Infect. 2004 Dec;132(6):1109-14. doi: 10.1017/s0950268804002833.
The epidemiological features and clinical manifestations of adult cases of brucellosis admitted to the Department of Infectious Diseases, Babol Medical University, Iran from 1997 to 2002 were investigated. Of 469 cases, 267 (56.9%) were males. The mean age of cases was 36.9 +/- 15 years. Most (60.8%) were from rural areas. Two thirds of cases (306, 66.3%) presented during spring or summer. Fresh cheese (22.4%), animal husbandry (11.3%), laboratory worker (8.1%) and veterinary profession (1.5%) were the main risk factors. Forty-five families (9.6%) had two cases. Sweating, fever, and arthralgia were the most frequent clinical symptoms. Complications were documented in 105 males (39.5%) and 41 females (20.3%, P=0.0001). Peripheral arthritis was seen in 24 (9%) males and 19 (9.4%) females, with knees and hips being the most common sites of infection. Sacroiliitis and spondylitis were seen in 28 (6%) and 32 (6.8%) cases respectively with spondylitis more common in males (P=0.023). Epididymo-orchitis was seen in 29 (10.9%) males. There were three cases each of endocarditis (0.6%) and neurological complications (0.6%). Most patients with brucellosis did not have any of the known risk factors for brucellosis. Thus consumption of unsafe dairy products could be the main route of infection. The disease manifested with a diversity of clinical manifestations and complications. Complications were more frequent in males than females.
对1997年至2002年期间伊朗巴博勒医科大学传染病科收治的成年布鲁氏菌病病例的流行病学特征和临床表现进行了调查。469例病例中，267例（56.9%）为男性。病例的平均年龄为36.9±15岁。大多数（60.8%）来自农村地区。三分之二的病例（306例，66.3%）在春季或夏季发病。新鲜奶酪（22.4%）、畜牧业（11.3%）、实验室工作人员（8.1%）和兽医职业（1.5%）是主要危险因素。45个家庭（9.6%）有两例病例。出汗、发热和关节痛是最常见的临床症状。105名男性（39.5%）和41名女性（20.3%，P = 0.0001）有并发症记录。24名男性（9%）和19名女性（9.4%）出现外周关节炎，膝关节和髋关节是最常见的感染部位。分别有28例（6%）和32例（6.8%）出现骶髂关节炎和脊柱炎，脊柱炎在男性中更常见（P = 0.023）。29名男性（10.9%）出现附睾炎或睾丸炎。心内膜炎和神经并发症各有3例（0.6%）。大多数布鲁氏菌病患者没有任何已知的布鲁氏菌病危险因素。因此，食用不安全的乳制品可能是主要感染途径。该疾病表现出多种临床表现和并发症。男性并发症比女性更常见。
