Crighton Eric J, Moineddin Rahim, Mamdani Muhammad, Upshur Ross E G
Primary Care Research Unit, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada.
Epidemiol Infect. 2004 Dec;132(6):1167-74. doi: 10.1017/s0950268804002924.
A comprehensive examination of gender and age-specific influenza and pneumonia hospitalization seasonality is currently lacking. Using population-based data for Ontario, Canada between April 1988 and March 2002 (n = 339,803 hospitalizations), findings from this study revealed clear seasonality [Fisher's Kappa (FK) test = 68.64, P < 0.001; Bartlett's Kolmogorov-Smirnov (BKS) test = 0.68, P < 0.001] with consistent summer troughs and winter peaks for both sexes and all ages combined. The very young (both sexes 0-4 years) demonstrated the strongest seasonality (R2(autoreg) = 0.97) and females aged 10-19 years, the weakest (R2(autoreg) = 0.59). Gender differences were most pronounced in the oldest age groups (80+ years) where females had an average annualized peak rate of 250/100,000 compared to 400/100,000 for males. These findings can contribute to more population-specific prevention strategies and effective resource and service allocation based on seasonal and specific population demands.
目前缺乏对特定性别和年龄的流感及肺炎住院季节性的全面研究。利用1988年4月至2002年3月期间加拿大安大略省的基于人群的数据（339,803例住院病例），本研究结果显示出明显的季节性[费舍尔卡方（FK）检验=68.64，P<0.001；巴特利特柯尔莫哥洛夫-斯米尔诺夫（BKS）检验=0.68，P<0.001]，男女和所有年龄段合计均呈现一致的夏季低谷和冬季高峰。年龄非常小的人群（0至4岁的男女）季节性最强（自回归R2=0.97），而10至19岁的女性季节性最弱（自回归R2=0.59）。性别差异在最年长的年龄组（80岁及以上）最为明显，其中女性的年化平均峰值率为250/10万，而男性为400/10万。这些发现有助于制定更具针对性的预防策略，并根据季节性和特定人群需求进行有效的资源和服务分配。
