Meenakshi-Sundaram S, Sinha S, Rao M, Prashanth L K, Arunodaya G R, Rao S, Swamy H S, Taly A B
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore.
J Assoc Physicians India. 2004 Apr;52:294-6.
Wilson's disease is known for its protean manifestations; however electrocardiographic abnormalities have not received much attention.
To evaluate the various electrocardiographic (ECG) changes in patients with Wilson's disease.
The resting ECGs of 50 patients with Wilson's disease were systematically analyzed independently by three observers after excluding other causes that could induce ECG abnormalities.
Fifteen patients had at least one abnormality in the ECG. Sinus tachycardia was seen in eight and sinus bradycardia in six. Other abnormalities included: bifid P wave (1), ST elevation (2), ST depression (2), T inversion (4), ventricular premature contraction - VPC (1) and prominent U waves (1). QRS axis, PR interval, QRS complex, R/S amplitude ratio and QT interval were normal in all. Ventricular premature beats were not recorded in any. None had features of ventricular hypertrophy. There was no statistically significant difference in ECG abnormalities with reference to age, gender, duration of illness or treatment, serum copper or ceruloplasmin, and severity of neurological impairment.
ECG abnormalities are not uncommon in Wilson's disease and are presumably related to an underlying cardiomyopathy due to deposition of copper in heart.
威尔逊病以其多样的表现而闻名；然而，心电图异常尚未受到太多关注。
评估威尔逊病患者的各种心电图变化。
在排除其他可能诱发心电图异常的原因后，由三名观察者独立系统地分析50例威尔逊病患者的静息心电图。
15例患者的心电图至少有一项异常。窦性心动过速8例，窦性心动过缓6例。其他异常包括：双峰P波（1例）、ST段抬高（2例）、ST段压低（2例）、T波倒置（4例）、室性早搏（1例）和明显U波（1例）。所有患者的QRS轴、PR间期、QRS波群、R/S波幅比值和QT间期均正常。未记录到任何室性早搏。无任何心室肥厚特征。在年龄、性别、病程或治疗、血清铜或铜蓝蛋白以及神经功能损害严重程度方面，心电图异常无统计学显著差异。
心电图异常在威尔逊病中并不少见，可能与铜在心脏沉积导致的潜在心肌病有关。
