Sendrowski K, Sobaniec W, Sobaniec-Lotowska M E, Lewczuk P
Department of Child Neurology & Rehabilitation, Medical University of Bialystok, Poland.
Rocz Akad Med Bialymst. 2004;49 Suppl 1:236-8.
S-100 is a structural protein of the central nervous system. An elevated level of S-100 in CSF is generally considered to be a marker of nervous tissue damage. The presence of this protein in blood serum points to the functional and/or morphological disruption of the blood-brain barrier. We measured S-100 in the cerebrospinal fluid and blood of children with two of the most often observed pathological states in child neurology--internal hydrocephalus and epilepsy. High levels of S-100 in CSF were detectable in children with internal hydrocephalus. Increased blood levels of S-100 protein were detectable in both groups of paediatric patients. Our preliminary results indicate neuronal damage in internal hydrocephalus and morphological and/or functional disturbances of the blood-brain barrier (their increased permeability) in both above mentioned disabilities.
S - 100是中枢神经系统的一种结构蛋白。脑脊液中S - 100水平升高通常被认为是神经组织损伤的标志物。血清中该蛋白的存在表明血脑屏障存在功能和/或形态学破坏。我们测量了儿童神经病学中两种最常见病理状态——内部脑积水和癫痫——患儿的脑脊液和血液中的S - 100。内部脑积水患儿的脑脊液中可检测到高水平的S - 100。两组儿科患者的血液中S - 100蛋白水平均有升高。我们的初步结果表明，内部脑积水中存在神经元损伤，上述两种疾病中均存在血脑屏障的形态学和/或功能紊乱（其通透性增加）。
