• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Tau in neurodegenerative diseases: tau phosphorylation and assembly.

作者信息

Avila J, Pérez M, Lim F, Gómez-Ramos A, Hernández F, Lucas J J

机构信息

Centro de Biología Molecular Severo Ochoa (CSIC-UAM). Facultad de Ciencias.Campus de Cantoblanco. Universidad Autónoma de Madrid, 28049 Madrid, Spain.

出版信息

Neurotox Res. 2004;6(6):477-82. doi: 10.1007/BF03033284.

DOI:10.1007/BF03033284
PMID:15639780
Abstract

The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment using a tau transgenic mouse model.

摘要

相似文献

1
Tau in neurodegenerative diseases: tau phosphorylation and assembly.
Neurotox Res. 2004;6(6):477-82. doi: 10.1007/BF03033284.
2
Neurodegenerative tauopathies: human disease and transgenic mouse models.神经退行性tau蛋白病：人类疾病与转基因小鼠模型
Neuron. 1999 Nov;24(3):507-10. doi: 10.1016/s0896-6273(00)81106-x.
3
Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration.与tau蛋白介导的神经退行性变相关的发动蛋白-1蛋白水平变化。
Neuroreport. 2012 Nov 14;23(16):942-6. doi: 10.1097/WNR.0b013e32835982ce.
4
A mouse model to study tau pathology related with tau phosphorylation and assembly.一种用于研究与tau磷酸化和组装相关的tau病理学的小鼠模型。
J Neurol Sci. 2007 Jun 15;257(1-2):250-4. doi: 10.1016/j.jns.2007.01.047. Epub 2007 Mar 23.
5
Pathogenic tau does not drive activation of the unfolded protein response.致病tau 不会驱动未折叠蛋白反应的激活。
J Biol Chem. 2019 Jun 21;294(25):9679-9688. doi: 10.1074/jbc.RA119.008263. Epub 2019 May 3.
6
Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.参与阿尔茨海默病、tau蛋白病及APP转基因小鼠中tau蛋白磷酸化的应激激酶。
Neurotox Res. 2004;6(6):469-75. doi: 10.1007/BF03033283.
7
Tau cleavage and tau aggregation in neurodegenerative disease.神经退行性疾病中的 Tau 裂解和 Tau 聚集。
Biochem Soc Trans. 2010 Aug;38(4):1016-20. doi: 10.1042/BST0381016.
8
Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau.对与tau蛋白相关的神经退行性疾病的当前认识
Mayo Clin Proc. 2017 Aug;92(8):1291-1303. doi: 10.1016/j.mayocp.2017.04.016.
9
[Animal models of tauopathies].[tau蛋白病的动物模型]
Rinsho Shinkeigaku. 2006 Nov;46(11):928-30.
10
Tau phosphorylation: physiological and pathological consequences.Tau蛋白磷酸化：生理与病理后果
Biochim Biophys Acta. 2005 Jan 3;1739(2-3):280-97. doi: 10.1016/j.bbadis.2004.06.017.

引用本文的文献

1
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.通过汉茨希反应设计与合成多功能配体：靶向钙通道、激活核因子E2相关因子2并具有组织蛋白酶S抑制及抗氧化特性
Pharmaceutics. 2024 Jan 17;16(1):121. doi: 10.3390/pharmaceutics16010121.
2
Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights.Rlip 减少诱导表达突变型 Tau 的永生化海马神经元中的氧化应激和线粒体功能障碍：机制见解。
Cells. 2023 Jun 16;12(12):1646. doi: 10.3390/cells12121646.
3

本文引用的文献

1
Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments.在 Sf9 昆虫细胞中表达一种改变形式的 tau 会导致聚合物组装，这些聚合物类似于阿尔茨海默病的双螺旋丝。
Brain Res. 2004 May 8;1007(1-2):57-64. doi: 10.1016/j.brainres.2004.01.071.
2
Modeling tau polymerization in vitro: a review and synthesis.体外tau蛋白聚合建模：综述与综合分析
Biochemistry. 2003 Dec 30;42(51):15009-17. doi: 10.1021/bi035722s.
3
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.
探索磺胺-二氢吡啶杂合体作为阿尔茨海默病治疗多靶点配体的潜力。
Int J Mol Sci. 2023 Jun 4;24(11):9742. doi: 10.3390/ijms24119742.
4
The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation.新型无毒淀粉样蛋白形成抑制剂的研发策略。
Int J Mol Sci. 2023 Feb 14;24(4):3781. doi: 10.3390/ijms24043781.
5
Elevating the Levels of Calcium Ions Exacerbate Alzheimer's Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau.钙离子水平升高通过诱导β-淀粉样蛋白和磷酸化 tau 的产生和聚集加重阿尔茨海默病。
Int J Mol Sci. 2021 May 31;22(11):5900. doi: 10.3390/ijms22115900.
6
Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts.单次和反复闭合性头部撞击后海马突触持续的病理生理学变化
Front Cell Neurosci. 2021 Mar 31;15:652721. doi: 10.3389/fncel.2021.652721. eCollection 2021.
7
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives.作为乙酰胆碱酯酶和钙通量抑制剂、抗氧化剂和神经保护剂的 Hantzsch 加合物的合成。
Int J Mol Sci. 2020 Oct 16;21(20):7652. doi: 10.3390/ijms21207652.
8
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels.新型抗氧化和神经保护多靶点导向配体的设计、合成与生物评价，该配体能阻断钙通道。
Molecules. 2020 Mar 14;25(6):1329. doi: 10.3390/molecules25061329.
9
ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins.重新绘制微管图谱：磷酸化如何决定微管相关蛋白的活性。
Dev Dyn. 2018 Jan;247(1):138-155. doi: 10.1002/dvdy.24599. Epub 2017 Oct 27.
10
Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats.氯胺酮诱导新生大鼠海马 tau 丝氨酸 404 过度磷酸化。
Neural Regen Res. 2013 Jun 15;8(17):1590-6. doi: 10.3969/j.issn.1673-5374.2013.17.007.
慢性锂治疗可减少转基因小鼠模型中突变tau蛋白的聚集。
J Alzheimers Dis. 2003 Aug;5(4):301-8. doi: 10.3233/jad-2003-5405.
4
beta-Amyloid induces paired helical filament-like tau filaments in tissue culture.β-淀粉样蛋白在组织培养中诱导出成对螺旋丝样tau蛋白细丝。
J Biol Chem. 2003 Oct 10;278(41):40162-8. doi: 10.1074/jbc.M308243200. Epub 2003 Jul 31.
5
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.鸡脑tau蛋白的分子克隆与功能特性：具有多达五个串联重复序列的异构体
Biochemistry. 2002 Dec 24;41(51):15203-11. doi: 10.1021/bi026464m.
6
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.阿尔茨海默病的β-淀粉样肽会与胰岛素竞争结合胰岛素受体。
J Neurosci. 2002 May 15;22(10):RC221. doi: 10.1523/JNEUROSCI.22-10-j0001.2002. Epub 2002 May 10.
7
Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity.结构微管相关蛋白（MAPs）在神经元极性发育中的作用。
J Neurosci Res. 2002 Mar 15;67(6):713-9. doi: 10.1002/jnr.10161.
8
Formation of aberrant phosphotau fibrillar polymers in neural cultured cells.
Eur J Biochem. 2002 Mar;269(5):1484-9. doi: 10.1046/j.1432-1033.2002.02794.x.
9
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.暴露于β淀粉样肽后神经元蛋白（包括tau蛋白和粘着斑激酶）的快速酪氨酸磷酸化：Src家族蛋白激酶的参与
J Neurosci. 2002 Jan 1;22(1):10-20. doi: 10.1523/JNEUROSCI.22-01-00010.2002.
10
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain.tau转基因小鼠中的额颞叶痴呆伴帕金森综合征17型（FTDP-17）突变引发前脑溶酶体异常和Tau细丝。
Mol Cell Neurosci. 2001 Dec;18(6):702-14. doi: 10.1006/mcne.2001.1051.