[乙醛脱氢酶（ALDH2）多态性与饮酒行为]
[Aldehyde dehydrogenase (ALDH2) polymorphism and drinking behavior].
作者信息
Luo Huai-Rong, Zhang Ya-Ping
机构信息
Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.
出版信息
Yi Chuan. 2004 Mar;26(2):263-6.
An atypical allele (ALDH2*2) in low K(m) aldehyde dehydrogenase (ALDH2), which is highly prevalent in Asians, may influence drinking behavior because of higher production of acetaldehyde in the liver. High alcohol sensitivity such as flushing after drinking has been shown to be mainly due to the atypical ALDH2 genotypes. The atypical allele is associated with alcohol-induced liver injury and some cancers. Recently, the researches on the polymorphisms not only in the gene itself but also its frequencies in different Asian populations have been made great progress. Three factors, including different sex, age and geography, were also analyzed with the genotypes of ALDH2 in Chinese populations.
低 Km 醛脱氢酶（ALDH2）中的一种非典型等位基因（ALDH2*2）在亚洲人中高度普遍，由于其在肝脏中会产生更多乙醛，可能会影响饮酒行为。饮酒后脸红等高酒精敏感性已被证明主要归因于非典型的 ALDH2 基因型。该非典型等位基因与酒精性肝损伤和某些癌症有关。最近，关于该基因本身的多态性及其在不同亚洲人群中的频率的研究取得了很大进展。还在中国人群中分析了性别、年龄和地理位置这三个因素与 ALDH2 基因型的关系。
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