Souza Anita Hermínia O, Salvatori Roberto, Martinelli Carlos E, Carvalho Walter M O, Menezes Carlos A, Barretto Elenilde S de A, Barreto Filho José A S, Alcântara Marta R S de, Oliveira Carla R P, Alcântara Paula R S de, Ramalho Roberto J R, Oliveira Hélio A, Lima Ivana B de, Carneiro Jamille N, Santos Marcos M, Gill Matthew S, Clayton Peter E, Oliveira Manuel H A
Serviço de Endocrinologia, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, SE.
Arq Bras Endocrinol Metabol. 2004 Jun;48(3):406-13. doi: 10.1590/s0004-27302004000300013. Epub 2004 Aug 26.
In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.
除了刺激身体生长外，生长激素或促生长激素在新陈代谢、身体组成、血脂状况、心血管状态和寿命方面也发挥着重要作用。其调控受到激素、代谢物和下丘脑肽的多重调节。本文回顾了伊塔巴亚尼尼亚县个体中IVS1+1G→A GHRH受体基因突变被描述后所获得的孤立性生长激素缺乏症（IGHD）的数据。探讨了关于生长激素抵抗模型、GHRH在生长激素分泌控制中的重要性、GHRH-R基因突变频率、IGF-I的诊断相关性以及代谢、心血管和生活质量研究结果的新观点。
