Divisão de Endocrinologia, Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brasil,
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA.
Arch Endocrinol Metab. 2022 Nov 17;66(6):919-928. doi: 10.20945/2359-3997000000567.
In the late 19 century, José Dantas de Souza Leite, a physician born in Sergipe, published the first detailed clinical description of acromegaly under the guidance of the French neurologist Pierre Marie. In 2014, the Brazilian Society of Endocrinology and Metabolism created the "José Dantas de Souza Leite Award", which is granted every two years to a Brazilian researcher who has contributed to the development of endocrinology. In 2022, the award was given to another physician from Sergipe, Manuel Hermínio de Aguiar Oliveira, from the Federal University of Sergipe for the description of "Itabaianinha syndrome" in a cohort of individuals with isolated GH deficiency due to a homozygous inactivating mutation in the GH-releasing hormone receptor gene. This research, which was carried out over almost 30 years, was performed in partnership with Roberto Salvatori from Johns Hopkins University and in collaboration with other researchers around the world. This review article tells the story of Souza Leite, some milestones in the history of GH, and summarizes the description of Itabaianinha syndrome.
19 世纪末期，出生于塞尔希培州的内科医师何塞·丹塔斯·德苏扎·莱特在法国神经学家皮埃尔·玛丽的指导下，发表了肢端肥大症的首个详细临床描述。2014 年，巴西内分泌学会设立了“何塞·丹塔斯·德苏扎·莱特奖”，每两年颁发给一位为内分泌学发展做出贡献的巴西研究人员。2022 年，该奖项授予塞尔希培州另一位内科医师曼努埃尔·赫米尼奥·德阿吉亚尔·奥利韦拉，他在因生长激素释放激素受体基因纯合失活突变而导致孤立性生长激素缺乏的个体队列中描述了“伊塔巴亚宁哈综合征”。这项研究历时近 30 年，与约翰霍普金斯大学的罗伯托·萨尔瓦托里合作完成，并与世界各地的其他研究人员合作开展。这篇综述文章讲述了苏扎·莱特的故事、生长激素的一些里程碑，以及总结了伊塔巴亚宁哈综合征的描述。
