Castro Rodrigo F, Maia Frederico F R, Ferreira Antônio R, Purisch Saulo, Calsolari Maria R, Menezes Patrícia A F C, Victória Ivana Maria N
Centro de Estudos e Pesquisas, Clínica de Endocrinologia e Metabologia, Departamento de Adrenal, Santa Casa de Belo Horizonte, MG.
Arq Bras Endocrinol Metabol. 2004 Jun;48(3):419-22. doi: 10.1590/s0004-27302004000300015. Epub 2004 Aug 26.
Pregnancy is a rare occurrence in Cushing's syndrome (CS) and it is associated with severe arterial hypertension in 64.6% of cases; infertility and abortion occur in 75% of patients with CS. In the event of a pregnancy in CS the etiology of hypercortisolism is the cortisol-producing adrenal adenoma in most cases. A most severe complication of high blood pressure in pregnancy is the HELLP syndrome. We report two cases of pregnancy in patients with CS, who developed a severe, sudden and early situation of HELLP syndrome which progressed to fetal death. The first was caused by an adrenal adenoma and the second by an adrenal carcinoma. Pregnancy due to CS can lead to a serious life-threatening situation, like the HELLP syndrome. Special attention should be paid when pregnancy is associated to CS. Early diagnosis leads to specific treatment, in an attempt to reduce de high morbid-mortality in these cases.
库欣综合征（CS）患者怀孕较为罕见，64.6%的病例伴有严重动脉高血压；75%的CS患者会出现不孕和流产。CS患者怀孕时，多数情况下高皮质醇血症的病因是分泌皮质醇的肾上腺腺瘤。妊娠期高血压最严重的并发症是HELLP综合征。我们报告了2例CS患者怀孕的病例，她们均出现了严重、突发且早期的HELLP综合征情况，并进展为胎儿死亡。第一例由肾上腺腺瘤引起，第二例由肾上腺皮质癌引起。CS导致的怀孕可能会引发严重危及生命的情况，如HELLP综合征。当怀孕与CS相关时应予以特别关注。早期诊断有助于进行针对性治疗，以降低这些病例的高病亡率。
