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[硬化性腹膜炎作为腹膜透析并发症但无超滤量减少]

[Sclerosing peritonitis without reduced ultrafiltration as complication of peritoneal dialysis].

作者信息

von Schnakenburg C, Pohl M, Häffner K, Zimmerhackl L B, Brandis M

机构信息

Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Freiburg, Freiburg.

出版信息

Klin Padiatr. 2005 Jan-Feb;217(1):41-4. doi: 10.1055/s-2004-822801.

DOI:10.1055/s-2004-822801
PMID:15640972
Abstract

UNLABELLED

Peritoneal dialysis (PD) is the preferred method of renal replacement therapy in childhood and adolescence while waiting for a kidney transplant. As major complication, encapsulating peritoneal sclerosis (EPS), sometimes also referred to as "sclerosing peritonitis", may develop after prolonged periods of PD and lead to severe therapeutical problems.

CASE REPORT

A 20-year-old patient with a history of three unsuccessful kidney transplants due to recurrence of his focal segmental glomerulosclerosis presented after 9 years of PD with acute abdominal pain and reduced bowel movements. Infectious peritonitis was excluded, ultrafiltration with 800-1 000 ml per day with low (1,36 %) glucose dialysate was not impaired. Plain abdominal X-ray, ultrasound and CT-scan illustrated characteristic peritoneal calcifications. Diagnosis of EPS was confirmed by peritoneal biopsy. The patients was switched to hemodialysis, enteral nutrition was continued, and the follow-up (now 16 months) was uncomplicated with the exception of a sterile ascites, which was twice relieved. Diagnostic and therapeutic options are discussed.

CONCLUSION

In contrast to most reports, EPS may develop with unchanged ultrafiltration after prolonged periods of PD. We recommend regular functional and imaging studies in patients at risk.

摘要

未标注

腹膜透析(PD)是儿童和青少年等待肾移植期间首选的肾脏替代治疗方法。作为主要并发症,包裹性腹膜硬化(EPS),有时也称为“硬化性腹膜炎”,可能在长期腹膜透析后发生,并导致严重的治疗问题。

病例报告

一名20岁患者,因局灶节段性肾小球硬化复发,经历了三次肾移植均失败,在腹膜透析9年后出现急性腹痛和排便减少。排除感染性腹膜炎,使用低浓度(1.36%)葡萄糖透析液每日超滤800 - 1000毫升未受影响。腹部平片、超声和CT扫描显示有特征性腹膜钙化。腹膜活检确诊为EPS。患者转为血液透析,继续肠内营养,随访(目前16个月)除出现两次自行缓解的无菌性腹水外,无其他并发症。讨论了诊断和治疗选择。

结论

与大多数报告不同,长期腹膜透析后超滤功能未改变时也可能发生EPS。我们建议对有风险的患者进行定期功能和影像学检查。

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引用本文的文献

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Encapsulating peritoneal sclerosis in children.儿童包裹性腹膜硬化症
Pediatr Nephrol. 2014 Nov;29(11):2093-103. doi: 10.1007/s00467-013-2672-8. Epub 2013 Nov 21.