[转移抑制基因KAI1/CD82在宫颈鳞状细胞癌中的表达及其临床意义]

[Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance].

作者信息

Xiong Ying, Liang Li-Zhi, Yan Xiao-Jian, Yuan Song-Hua, Wei Mei

机构信息

Department of Gynecologic Oncology, Caner Center, Sun Yat-sen University, Guangzhou, Guangdong 510-060, P.R. China.

出版信息

Ai Zheng. 2005 Jan;24(1):110-5.

PMID:15642213

Abstract

BACKGROUND & OBJECTIVE: Metastasis suppressor gene KAI1/CD82 plays an important role in infiltration and metastasis of several types of human cancers, while the researches on its relation with cervical carcinoma are far from adequate now. Therefore, immunohistochemical techniques were employed in this study to determine the expression of KAI1 gene, and explore its clinical significance in cervical squamous cell carcinoma.

METHODS

SP immunohistochemistry was used to detect the expression of KAI1 gene in 99 specimens of cervical squamous cell carcinoma, 25 specimens of cervical intraepithelial neoplasm (CIN) II-III, and 18 specimens of normal cervix. Correlations of expression of KAI1 gene to clinicopathologic factors, and prognosis of cervical squamous cell carcinoma were statistically analyzed.

RESULTS

The rates of negative, weak, moderate, and strong expression of KAI1 in cervical squamous cell carcinoma were 52.5% (52/99), 16.2% (16/99), 15.2% (15/99), and 16.2% (16/99), respectively, significantly lower than those in normal cervix, and CIN II-III (P=0.000). Expression of KAI1 has no correlation with FIGO stage, age, pelvic lymph node metastasis, tumor histological grade, depth of cervical infiltration, serum squamous cell carcinoma antigen (SCC) level, tumor size, and gross type of cervical lesion (P>0.05). Both univariate and multivariate analyses showed expression of KAI1 has no correlation with prognosis of cervical squamous cell carcinoma (P>0.05).

CONCLUSION

KAI1 gene may be an early event in development of cervical cancer, and has no correlation with prognosis of cervical squamous cell carcinoma.

摘要

背景与目的

转移抑制基因KAI1/CD82在多种人类癌症的浸润和转移中起重要作用，但其与宫颈癌关系的研究目前尚不充分。因此，本研究采用免疫组化技术检测KAI1基因的表达，并探讨其在宫颈鳞状细胞癌中的临床意义。

方法

采用SP免疫组化法检测99例宫颈鳞状细胞癌标本、25例宫颈上皮内瘤变（CIN）II-III标本及18例正常宫颈标本中KAI1基因的表达。对KAI1基因表达与宫颈鳞状细胞癌临床病理因素及预后的相关性进行统计学分析。

结果

KAI1在宫颈鳞状细胞癌中的阴性、弱阳性、中度阳性和强阳性表达率分别为52.5%（52/99）、16.2%（16/99）、15.2%（15/99）和16.2%（16/99），显著低于正常宫颈和CIN II-III（P=0.000）。KAI1的表达与国际妇产科联盟（FIGO）分期、年龄、盆腔淋巴结转移、肿瘤组织学分级、宫颈浸润深度、血清鳞状细胞癌抗原（SCC）水平、肿瘤大小及宫颈病变大体类型均无相关性（P>0.05）。单因素和多因素分析均显示KAI1的表达与宫颈鳞状细胞癌的预后无相关性（P>0.05）。