Wei Heng, Wang Ning, Zhang Yao, Wang Shizhuo, Pang Xiaoao, Zhang Jing, Luo Qingshuang, Su Youbo, Zhang Shulan
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China.
Med Oncol. 2014 May;31(5):933. doi: 10.1007/s12032-014-0933-4. Epub 2014 Apr 16.
The purpose of the study was to determine the expression patterns of Wnt-11 and squamous cell carcinoma antigen in cervical cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters. The expression of Wnt-11 and squamous cell carcinoma antigen was detected in 127 cervical cancer tissues, 21 cervical intraepithelial neoplasia, as well as in 20 healthy controls by immunohistochemistry, and the relationship of Wnt-11 and squamous cell carcinoma antigen expression with clinicopathological parameters was analyzed. Both Wnt-11 and squamous cell carcinoma antigen were more commonly expressed in cervical cancer than in cervical intraepithelial neoplasia and in normal cervical tissue (respectively; P < 0.05); further, Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer were positively correlated (r = 0.271, P < 0.05). In comparing the expression with clinicopathological parameters of tumor samples, Wnt-11 and squamous cell carcinoma antigen were both associated with FIGO stage, lymph node metastasis, and tumor size (P < 0.05), but not with patient age, pathological type, or differentiation. Increased Wnt-11 protein levels in cervical carcinoma samples were associated with a poor outcome in univariate and multivariate analysis. Wnt-11 and squamous cell carcinoma antigen are related to the malignancy degree and metastasis of cervical cancer, and thus may play a coordinating role in the occurrence and progression of cervical cancer. The study indicated that Wnt-11 may be a useful prognostic indicator for cervical carcinoma.
本研究的目的是确定Wnt-11和鳞状细胞癌抗原在宫颈癌组织中的表达模式，并探讨其临床意义以及与临床病理参数的相关性。通过免疫组织化学检测了127例宫颈癌组织、21例宫颈上皮内瘤变组织以及20例健康对照中Wnt-11和鳞状细胞癌抗原的表达情况，并分析了Wnt-11和鳞状细胞癌抗原表达与临床病理参数的关系。Wnt-11和鳞状细胞癌抗原在宫颈癌中的表达均比宫颈上皮内瘤变和正常宫颈组织更为常见（均P < 0.05）；此外，宫颈癌中Wnt-11和鳞状细胞癌抗原的表达呈正相关（r = 0.271，P < 0.05）。在将肿瘤样本的表达与临床病理参数进行比较时，Wnt-11和鳞状细胞癌抗原均与国际妇产科联盟（FIGO）分期、淋巴结转移及肿瘤大小相关（P < 0.05），但与患者年龄、病理类型或分化程度无关。在单因素和多因素分析中，宫颈癌样本中Wnt-11蛋白水平升高与不良预后相关。Wnt-11和鳞状细胞癌抗原与宫颈癌的恶性程度和转移有关，因此可能在宫颈癌的发生和发展中起协同作用。该研究表明，Wnt-11可能是宫颈癌一个有用的预后指标。
