生物医学研究实验室中与母体接触特定物质相关的先天性畸形。

Congenital malformations related to maternal exposure to specific agents in biomedical research laboratories.

作者信息

Wennborg Helena, Magnusson Linda L, Bonde Jens Peter, Olsen Jørn

机构信息

Department of Biosciences, Novum Research Park, Karolinska Institutet, Sweden.

出版信息

J Occup Environ Med. 2005 Jan;47(1):11-9. doi: 10.1097/01.jom.0000150237.67801.93.

DOI:10.1097/01.jom.0000150237.67801.93

PMID:15643154

Abstract

OBJECTIVE

To investigate major congenital and neural crest malformations (NCM; craniofacial and conotruncal defects) in the offspring of laboratory employees.

METHODS

Data for 1951 females was linked to the Medical Birth Register (3003 pregnancies). Exposure information was based on questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

RESULTS

The prevalence of "major malformations" were 2.3% (n = 41; exposed) and 1.9% (n = 23; unexposed). For the major malformations, solvent exposure before the third trimester gave an OR of 1.8 (CI = 1.0-2.9); "laboratory work in general," of 1.2 (CI = 0.7-2.0) unadjusted. OR for benzene use around conception/organogenesis was 5.3 (CI = 1.4-21.1) for NCM.

CONCLUSION

No significant risk for laboratory work in general was seen, but there was an increased ratio for NCM relative to solvents, especially benzene. These results are based on small numbers and should be interpreted cautiously.

摘要

目的

调查实验室工作人员后代中的主要先天性和神经嵴畸形（NCM；颅面和圆锥干缺陷）。

方法

1951名女性的数据与医疗出生登记册相关联（3003次妊娠）。暴露信息基于问卷调查。计算了95%置信区间（CI）的比值比（OR）。

结果

“主要畸形”的患病率在暴露组为2.3%（n = 41），未暴露组为1.9%（n = 23）。对于主要畸形，孕晚期前接触溶剂的OR为1.8（CI = 1.0 - 2.9）；未经调整的“一般实验室工作”的OR为1.2（CI = 0.7 - 2.0）。对于NCM，受孕/器官形成期前后使用苯的OR为5.3（CI = 1.4 - 21.1）。