Suaidi Noor Asyikin, Alshawsh Mohammed Abdullah, Hoe See-Ziau, Mokhtar Mohd Helmy, Zin Siti Rosmani Md
Department of Anatomy, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Toxics. 2022 May 4;10(5):235. doi: 10.3390/toxics10050235.
Technical xylene is a compound of massive production that is used in applications such as petrochemical and healthcare laboratories. Exposure to xylene can cause acute and chronic effects in humans and animals. Currently available studies regarding xylene's adverse effects with credible designs were dated almost twenty years ago. This systematic review summarizes the findings regarding the detrimental effects of technical xylene from human, animal, and in vitro studies. It recapitulated available studies with respect to the effects of xylene on the female reproductive system to stress the need for updating the current data and guidelines. Based on pre-specified criteria, 22 studies from journal databases exploring the toxic effects of xylene on menstruation, endocrine endpoints, fetal development, and reproductive functions were included for the review. It was found that related studies with a specific focus on the effects of technical xylene on the female reproductive system were insufficient. Therefore, further studies are necessary to update the existing data, thus improving the quality and reliability of risk assessment of exposure to xylene in pregnant women.
工业用二甲苯是一种大量生产的化合物，用于石油化工和医疗保健实验室等领域。接触二甲苯会对人类和动物造成急性和慢性影响。目前关于二甲苯不良反应且设计可靠的研究几乎都是近二十年前的。本系统综述总结了来自人体、动物和体外研究中有关工业用二甲苯有害影响的研究结果。它概述了关于二甲苯对女性生殖系统影响的现有研究，以强调更新当前数据和指南的必要性。根据预先设定的标准，从期刊数据库中纳入了22项探索二甲苯对月经、内分泌指标、胎儿发育和生殖功能毒性作用的研究进行综述。结果发现，专门关注工业用二甲苯对女性生殖系统影响的相关研究不足。因此，有必要进一步开展研究以更新现有数据，从而提高对孕妇接触二甲苯风险评估的质量和可靠性。
