The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain.
作者信息
Young Simon N, Shalchi Marjan
机构信息
Department of Psychiatry, McGill University, Montréal, QC.
出版信息
J Psychiatry Neurosci. 2005 Jan;30(1):44-8.
Abstract
OBJECTIVE
S-Adenosylmethionine (SAMe) is a major methyl donor in the brain and is also an antidepressant with few reported side effects; however, SAMe is relatively expensive and unstable. Brain SAMe can be increased by giving methionine to rats, raising the possibility that methionine may be an antidepressant. We aimed to study whether SAMe and methionine, when given orally to rats, could raise levels of SAMe in the central nervous system (CNS). We also aimed to test the relative abilities of SAMe and methionine to increase tail-flick latency after a thermal stimulus. This test was used to measure changes in CNS function.
METHODS
Rats were given SAMe and methionine orally at various doses, and biochemical and behavioural testing was carried out at intervals up to 6 hours later.
RESULTS
Methionine raised SAMe levels in various regions of the CNS and increased tail-flick latency, both at lower doses than SAMe.
CONCLUSION
Methionine should be tested for antidepressant properties in humans.
摘要
相似文献
1
The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain.
J Psychiatry Neurosci. 2005 Jan;30(1):44-8.
2
Intestinal absorption of S-adenosyl-L-methionine.
J Pharmacol Exp Ther. 1979 Jun;209(3):323-6.
3
Effect of methionine-loading on methyl group synthesis and activation in rat brain and liver.
Biol Psychiatry. 1978 Dec;13(6):661-9.
4
Effect of nitrous oxide and methionine on hepatic S-adenosylmethionine levels and in vivo histidine oxidation in rats.
Indian J Biochem Biophys. 1992 Oct;29(5):415-7.
5
Depletion of S-adenosyl-L-methionine in mouse brain by antidepressive drugs.
J Pharmacol Exp Ther. 1975 Aug;194(2):303-10.
6
7
8
Methylation hypothesis.
Arch Gen Psychiatry. 1979 Mar;36(3):303-7. doi: 10.1001/archpsyc.1979.01780030069006.
9
Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry.
Eur Neuropsychopharmacol. 2005 Oct;15(5):533-43. doi: 10.1016/j.euroneuro.2005.01.004.
10
Effect of L-dihydroxyphenylalanine (L-dopa) and methionine on tissue S-adenosylmethionine concentrations in cobalamin-inactivated fruit bats.
Int J Vitam Nutr Res. 1984;54(4):329-32.
引用本文的文献
1
Developmental modulation of schizophrenia risk gene methylation in offspring exhibiting cognitive deficits following maternal immune activation.
Mol Psychiatry. 2025 Aug 29. doi: 10.1038/s41380-025-03147-1.
2
Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the Gene in Huntington's Disease Brain Tissue.
Genes (Basel). 2023 Sep 2;14(9):1752. doi: 10.3390/genes14091752.
3
Antidepressant and Anxiolytic Effects of L-Methionine in the WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy.
Int J Mol Sci. 2023 Aug 4;24(15):12425. doi: 10.3390/ijms241512425.
4
Cerebrolysin Use in Patients with Liver Damage-A Translational Study.
Life (Basel). 2022 Nov 4;12(11):1791. doi: 10.3390/life12111791.
5
Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening.
Genes (Basel). 2022 Jun 27;13(7):1163. doi: 10.3390/genes13071163.
6
The effect of different dietary ratios of lysine and arginine in diets with high or low methionine levels on oxidative and epigenetic DNA damage, the gene expression of tight junction proteins and selected metabolic parameters in Clostridium perfringens-challenged turkeys.
Vet Res. 2020 Apr 7;51(1):50. doi: 10.1186/s13567-020-00776-y.
7
Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine.
Front Cell Infect Microbiol. 2020 Jan 29;9:470. doi: 10.3389/fcimb.2019.00470. eCollection 2019.
8
High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats.
Nutr Metab (Lond). 2020 Jan 6;17:2. doi: 10.1186/s12986-019-0422-z. eCollection 2020.
9
Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates.
Sci Rep. 2019 Jun 27;9(1):9364. doi: 10.1038/s41598-019-45170-7.
10
The effect of different dietary levels of DL-methionine and DL-hydroxy analogue on the antioxidant status of young turkeys infected with the haemorrhagic enteritis virus.
BMC Vet Res. 2018 Dec 17;14(1):404. doi: 10.1186/s12917-018-1727-2.
本文引用的文献
1
Homocysteine, folate, methylation, and monoamine metabolism in depression.
J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):228-32. doi: 10.1136/jnnp.69.2.228.
2
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.
Acta Neurol Scand Suppl. 1994;154:7-14. doi: 10.1111/j.1600-0404.1994.tb05403.x.
3
Stability-indicating proton nuclear magnetic resonance spectroscopic method for determination of S-adenosyl-L-methionine in tablets.
J AOAC Int. 1995 Mar-Apr;78(2):353-8.
4
S-adenosylmethionine levels in psychiatric and neurological disorders: a review.
Acta Neurol Scand Suppl. 1994;154:19-26. doi: 10.1111/j.1600-0404.1994.tb05405.x.
5
Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes.
J Neurochem. 1980 Jun;34(6):1491-8. doi: 10.1111/j.1471-4159.1980.tb11229.x.
6
Age-related modification of dopaminergic and beta-Adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine.
Life Sci. 1984 May 21;34(21):2029-39. doi: 10.1016/0024-3205(84)90367-9.
7
Phospholipid methylation and biological signal transmission.
Science. 1980 Sep 5;209(4461):1082-90. doi: 10.1126/science.6157192.
8
S-adenosylmethionine influences monoamine metabolism.
Lancet. 1984 Jul 28;2(8396):224. doi: 10.1016/s0140-6736(84)90507-5.
9
Folic acid, S-adenosylmethionine and affective disorder.
Psychol Med. 1983 Nov;13(4):705-10. doi: 10.1017/s0033291700051394.
10
S-adenosylmethionine in brain and other tissues.
J Neurochem. 1966 Aug;13(8):769-77. doi: 10.1111/j.1471-4159.1966.tb09884.x.
Zotero 插件