Merk H F
Universität-Hautklinik, Klinik für Dermatologie and Allergologie der RWTH Aachen.
Hautarzt. 2005 Jan;56(1):44-7. doi: 10.1007/s00105-004-0878-1.
Pharmacogenetics, pharmacogenomics or metabonomics are terms reflecting a new trend in pharmacology taking into consideration individual factors which influence the effects of drugs. Examples in dermatology include glucose-6-phosphate dehydrogenase-polymorphism (DADPS), dihydropyrimidine dehydrogenase-deficiency (5-Fluoruracil), thiopurine-S-methyltransferase-deficiency (azathioprine), cytochrome P450 isoenzymes and transferases (drug allergy and allergic contact dermatitis), and intolerant reactions to NSAIDs.
药物遗传学、药物基因组学或代谢组学是反映药理学新趋势的术语，该趋势考虑了影响药物效果的个体因素。皮肤病学中的例子包括葡萄糖-6-磷酸脱氢酶多态性（DADPS）、二氢嘧啶脱氢酶缺乏症（5-氟尿嘧啶）、硫嘌呤-S-甲基转移酶缺乏症（硫唑嘌呤）、细胞色素P450同工酶和转移酶（药物过敏和过敏性接触性皮炎），以及对非甾体抗炎药的不耐受反应。
