Pincelli Carlo, Pignatti Marco, Borroni Riccardo G
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
Exp Dermatol. 2009 Apr;18(4):337-49. doi: 10.1111/j.1600-0625.2009.00852.x.
A significant proportion of patients with skin disease do not respond to treatment and adverse drug reactions are a common problem. Genetic factors are important determinants for both drug efficacy and toxicity. The fields of pharmacogenetics and pharmacogenomics examine inter-individual variations in the DNA sequence that are related to drug efficacy and toxicity. Here, we present pharmacogenomic data relevant to dermatology and explore the role of dermatologists in identifying patients who may respond to treatment or experience adverse drug reactions.
相当一部分皮肤病患者对治疗无反应，药物不良反应是一个常见问题。遗传因素是药物疗效和毒性的重要决定因素。药物遗传学和药物基因组学领域研究与药物疗效和毒性相关的个体间DNA序列变异。在此，我们展示与皮肤病学相关的药物基因组学数据，并探讨皮肤科医生在识别可能对治疗有反应或经历药物不良反应的患者中的作用。
