Upfal M
Division of Occupational and Environmental Medicine, Wayne State University, Detroit, Michigan 48201.
J Occup Med. 1992 Apr;34(4):384-90.
Equipment maintenance workers within the microelectronics industry have opportunities for occupational exposure to a variety of toxic agents. This pilot investigation compares liver enzymes in this population with that of other coworkers. Participants (n = 135) were randomly selected from a medical surveillance program at the manufacturing facility. Nine job categories were examined, including equipment maintenance workers and electronic technicians. Although abnormal liver enzymes were detected among equipment maintenance workers (odds ratio 16.4; P less than .008) and electronic technicians (odds ratio 27; P less than .0005), the numbers of participants were small (n = 8, 10). The data suggest that independent and/or interactive etiologic roles of occupation and alcohol should be further investigated. Early detection of subclinical occupational or recreational hepatotoxicity with appropriate employment of industrial hygiene control technology and/or the reduction of alcohol consumption may provide a means of preventing liver disease.
微电子行业的设备维护工人有机会职业接触多种有毒物质。这项初步调查将该人群的肝酶与其他同事的肝酶进行了比较。参与者(n = 135)从制造工厂的医疗监测项目中随机选取。研究了九个工作类别,包括设备维护工人和电子技术员。虽然在设备维护工人(优势比16.4;P小于0.008)和电子技术员(优势比27;P小于0.0005)中检测到肝酶异常,但参与者数量较少(n = 8, 10)。数据表明,职业和酒精的独立和/或交互病因作用应进一步研究。通过适当采用工业卫生控制技术和/或减少酒精消费来早期发现亚临床职业性或娱乐性肝毒性,可能提供一种预防肝病的方法。