Tsypysheva Inna P, Lobov Alexander N, Kovalskaya Alena V, Petrova Polina R, Ivanov Sergey P, Rameev Shamil A, Borisevich Sophia S, Safiullin Rustam L, Yunusov Marat S
a Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences , 71, pr. Oktyabrya, 450054 Ufa , Russian Federation.
Nat Prod Res. 2015;29(2):141-8. doi: 10.1080/14786419.2014.968150. Epub 2014 Oct 21.
The first example of aza-Michael reaction of 12-N-carboxamide of quinolizidine alkaloid (-)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.
已描述了喹诺里西啶生物碱（-）-金雀花碱的12-N-羧酰胺与α,β-不饱和酮、乙炔二甲酸二甲酯和β-硝基苯乙烯在高压条件下进行氮杂-Michael反应的首个实例。结果表明，在与N-苯基马来酰亚胺反应的情况下会发生[4+2]环加成反应。
