Radi A, Elmogy T
Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt.
Farmaco. 2005 Jan;60(1):43-6. doi: 10.1016/j.farmac.2004.07.016. Epub 2004 Nov 11.
The electrochemical oxidation of antihypertensive drug carvedilol has been studied in pH range 2.0-11.0 at a glassy carbon electrode by cyclic and differential pulse voltammetry. Two oxidation processes were produced in different supporting electrolyte media. Both oxidation processes were irreversible and diffusion-controlled. The first oxidation process was chosen for the analysis of carvedilol. A very resolved voltammetric peak was obtained in Britton-Robinson buffer at pH 8.0 using differential pulse mode. The linear response was obtained in the range of 0.25-10.00 microg ml(-1). The limit of detection was found to be 0.10 microg ml(-1). The developed method was used for the determination of carvedilol in tablet dosage form.
采用循环伏安法和差分脉冲伏安法，在pH值为2.0 - 11.0的范围内，于玻碳电极上研究了抗高血压药物卡维地洛的电化学氧化。在不同的支持电解质介质中产生了两个氧化过程。这两个氧化过程均为不可逆的扩散控制过程。选择第一个氧化过程用于卡维地洛的分析。在pH值为8.0的Britton-Robinson缓冲溶液中，采用差分脉冲模式获得了一个分离良好的伏安峰。在0.25 - 10.00 μg ml⁻¹范围内获得线性响应。检测限为0.10 μg ml⁻¹。所建立的方法用于测定片剂剂型中的卡维地洛。
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