Radi A, El-Shahawi M S, Elmogy T
Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt.
J Pharm Biomed Anal. 2005 Feb 7;37(1):195-8. doi: 10.1016/j.jpba.2004.10.013.
The electrochemical oxidation of bromocriptine at glassy carbon electrode has been carried out in Britton-Robinson (B-R) buffer solutions in the pH range 2.0-11.0 employing cyclic, linear sweep and differential pulse voltammetry (DPV). Bromocriptine showed one well-defined oxidation peak accompanied by a smaller one. The oxidation process was found irreversible. For analytical purposes, the well-resolved diffusion controlled voltammetric peak at pH 5 was critically investigated. The linear relationship between peak current height and bromocriptine concentration allowed the differential pulse voltammetric determination of the drug over a wide concentration range, from 0.04 to 5.00 microg ml(-1) with a detection limit of 0.01 microg ml(-1). A relative standard deviation of 1.44% at 0.1 microg ml(-1) level was obtained. The proposed DPV method was successfully applied for the individual tablet assay to verify the uniformity content of bromocriptine in commercial tablets.
在pH值为2.0 - 11.0的Britton-Robinson（B-R）缓冲溶液中，采用循环伏安法、线性扫描伏安法和差分脉冲伏安法（DPV），研究了溴隐亭在玻碳电极上的电化学氧化行为。溴隐亭显示出一个清晰的氧化峰以及一个较小的氧化峰。发现氧化过程是不可逆的。为了分析目的，对pH 5时分辨率良好的扩散控制伏安峰进行了严格研究。峰电流高度与溴隐亭浓度之间的线性关系使得差分脉冲伏安法能够在0.04至5.00 μg ml⁻¹的宽浓度范围内测定该药物，检测限为0.01 μg ml⁻¹。在0.1 μg ml⁻¹水平下获得的相对标准偏差为1.44%。所提出的DPV方法成功应用于单个片剂分析，以验证市售片剂中溴隐亭含量的均匀性。
