磷脂对吉兰-巴雷综合征中抗神经节苷脂抗体反应性的影响。

Effects of phospholipids on antiganglioside antibody reactivity in GBS.

作者信息

Hirakawa Minako, Morita Daiji, Tsuji Shoji, Kusunoki Susumu

机构信息

Department of Neurology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.

出版信息

J Neuroimmunol. 2005 Feb;159(1-2):129-32. doi: 10.1016/j.jneuroim.2004.09.018. Epub 2004 Nov 5.

DOI:10.1016/j.jneuroim.2004.09.018

PMID:15652411

Abstract

Serum antibody activities to mixtures of a ganglioside and various phospholipids were compared with those to a ganglioside alone in 30 anti-GM1 IgG-positive GBS patients and 30 anti-GQ1b IgG-positive Miller Fisher syndrome (MFS) patients. Anti-GM1-positive sera had higher antibody reactivities against a mixture of GM1 and several phospholipids including PA, PI and PS, than against GM1 alone. In contrast, in case of anti-GQ1b antibody, no phospholipid provided significant enhancement. Sphingomyelin provided decrease of the activity for both anti-GM1 and anti-GQ1b IgG. The effects of phospholipids must be considered to determine the pathogenetic role of antiganglioside antibodies in GBS and MFS.

摘要

在30例抗GM1 IgG阳性的吉兰-巴雷综合征（GBS）患者和30例抗GQ1b IgG阳性的米勒费雪综合征（MFS）患者中，比较了血清对神经节苷脂与各种磷脂混合物的抗体活性和对单一神经节苷脂的抗体活性。抗GM1阳性血清对GM1与包括磷脂酸（PA）、磷脂酰肌醇（PI）和磷脂酰丝氨酸（PS）在内的几种磷脂的混合物的抗体反应性，高于对单一GM1的反应性。相比之下，对于抗GQ1b抗体，没有磷脂能显著增强其活性。鞘磷脂使抗GM1和抗GQ1b IgG的活性均降低。在确定抗神经节苷脂抗体在GBS和MFS中的致病作用时，必须考虑磷脂的影响。