费希尔综合征和吉兰-巴雷综合征中针对由脱唾液酸GM1与GQ1b或GT1a组成的神经节苷脂复合物的抗体。

Antibodies to ganglioside complexes consisting of asialo-GM1 and GQ1b or GT1a in Fisher and Guillain-Barré syndromes.

作者信息

Ogawa Go, Kaida Ken-ichi, Kusunoki Susumu, Ueda Masami, Kimura Fumihiko, Kamakura Keiko

机构信息

Division of Neurology, Department of Internal Medicine 3, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

出版信息

J Neuroimmunol. 2009 Sep 29;214(1-2):125-7. doi: 10.1016/j.jneuroim.2009.06.017. Epub 2009 Jul 24.

DOI:10.1016/j.jneuroim.2009.06.017

PMID:19631994

Abstract

To determine the epitopes of ganglioside complexes (GSCs) containing GQ1b or GT1a, we investigated their reactivity to GSCs consisting of asialo-GM1 (GA1) and GQ1b or GT1a using IgG anti-GQ1b- or anti-GT1a-positive sera. Nine anti-GQ1b-positive sera had higher activity to GA1/GQ1b than to GQ1b, only five of which reacted with GM1/GQ1b and GD1b/GQ1b. Five of 14 sera positive for GA1/GT1a and GM1/GT1a were negative for GA1/GQ1b and GM1/GQ1b. Sialic acids attached to the internal galactose of gangliotetraose can influence the reactivity of anti-GSC antibodies. Screening for antibodies to GSCs containing GA1 is useful for elucidation of the antibody-mediated pathophysiology.

摘要

为了确定含有GQ1b或GT1a的神经节苷脂复合物（GSCs）的表位，我们使用抗GQ1b或抗GT1a阳性血清研究了它们对由脱唾液酸GM1（GA1）与GQ1b或GT1a组成的GSCs的反应性。九份抗GQ1b阳性血清对GA1/GQ1b的活性高于对GQ1b的活性，其中只有五份与GM1/GQ1b和GD1b/GQ1b发生反应。14份对GA1/GT1a和GM1/GT1a呈阳性的血清中有五份对GA1/GQ1b和GM1/GQ1b呈阴性。连接在神经节四糖内部半乳糖上的唾液酸可影响抗GSC抗体的反应性。筛选针对含有GA1的GSCs的抗体有助于阐明抗体介导的病理生理学。