Akiyama Mayumi, Koga Michiaki, Yoshino Hiide, Hamaoka Akira, Noguchi Yasuhiko, Hirata Koichi, Yuki Nobuhiro
Shino-Test Corporation, 2-29-14 Oonodai, Sagamihara-shi, Kanagawa 229-0011, Japan.
No To Shinkei. 2006 Jun;58(6):477-81.
We developed testing kits for anti-GM1 and anti-GQ1b IgG antibodies and examined their utilities in supporting the diagnosis of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS). Anti-GM1 antibody was detected in 49% of 95 patients with GBS and in 5% or less of disease and normal controls. Anti-GQ1b antibody was detected in 85% of 55 patients with FS, whereas in none of the controls. Eight GBS patients, in whom anti-GM1 IgG antibody was judged negative using the kit, were found to have other anti-ganglioside IgG antibodies. Four of them showed ophthalmoplegia and had anti-GQ1b IgG antibody. Detection of anti-GM1 IgG antibody in GBS and of anti-GQ1b IgG antibody in FS within one week after the disease onset were significantly more frequent compared to albuminocytologic dissociation in the cerebrospinal fluids (GBS, 58% vs 32%; FS, 89% vs 20%). These findings indicate that our testing kits are useful for supporting the early diagnosis of GBS and FS.
我们开发了抗GM1和抗GQ1b IgG抗体检测试剂盒，并研究了它们在辅助诊断吉兰-巴雷综合征（GBS）和费舍尔综合征（FS）中的效用。在95例GBS患者中，49%检测到抗GM1抗体，而在疾病对照组和正常对照组中，该比例为5%或更低。在55例FS患者中，85%检测到抗GQ1b抗体，而在对照组中均未检测到。使用该试剂盒判断为抗GM1 IgG抗体阴性的8例GBS患者，被发现存在其他抗神经节苷脂IgG抗体。其中4例出现眼肌麻痹，且具有抗GQ1b IgG抗体。与脑脊液中的蛋白细胞分离相比，在疾病发作后1周内检测到GBS患者的抗GM1 IgG抗体和FS患者的抗GQ1b IgG抗体的频率显著更高（GBS，58%对32%；FS，89%对20%）。这些发现表明，我们的检测试剂盒有助于GBS和FS的早期诊断。
