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慢经颅磁刺激可迅速减轻精神分裂症患者的顽固性幻听症状。

Slow transcranial magnetic stimulation can rapidly reduce resistant auditory hallucinations in schizophrenia.

作者信息

Poulet Emmanuel, Brunelin Jérôme, Bediou Benoit, Bation Rémi, Forgeard Louis, Dalery Jean, d'Amato Thierry, Saoud Mohamed

机构信息

Vulnérabilité à la Psychose de la Prédiction à la Prévention, UCBL, France.

出版信息

Biol Psychiatry. 2005 Jan 15;57(2):188-91. doi: 10.1016/j.biopsych.2004.10.007.


DOI:10.1016/j.biopsych.2004.10.007
PMID:15652879
Abstract

BACKGROUND: Almost a quarter of patients with schizophrenia present with resistant auditory verbal hallucinations (AVH), a phenomenon that may relate to activation of brain areas underlying speech perception. Repetitive transcranial magnetic stimulation (rTMS) at 1 Hz reduces cortical activation, and recent results have shown that 1-Hz left temporoparietal rTMS may reduce AVH. The aim of this study was to replicate recent data and investigate whether low-frequency rTMS with a high total stimulation number delivered in a shorter 5-day block produces similar benefit. METHODS: Ten right-handed schizophrenia patients with resistant AVH received 5 days of active rTMS and 5 days of sham rTMS (2,000 stimulations per day at 90% of motor threshold) over the left temporoparietal cortex in a double-blind crossover design. The two weeks of stimulation were separated by a 1-week washout period. RESULTS: AVH were robustly improved (56%) by 5 days active rTMS, whereas no variation was observed after sham. Seven patients were responders to active treatment, five of whom maintained improvement for at least 2 months. CONCLUSIONS: These data confirm the efficiency of low-frequency rTMS applied to the left temporoparietal cortex, compared with sham stimulation, in reducing resistant AVH. This improvement can be obtained in only 5 days without serious initial adverse events.

摘要

背景:近四分之一的精神分裂症患者存在难治性幻听(AVH),这一现象可能与言语感知相关脑区的激活有关。1赫兹的重复经颅磁刺激(rTMS)可降低皮层激活,近期研究结果表明,1赫兹的左颞顶叶rTMS可能会减少幻听。本研究的目的是重复近期的数据,并调查在较短的5天疗程内给予高总刺激次数的低频rTMS是否能产生类似的效果。 方法:10名患有难治性幻听的右利手精神分裂症患者,采用双盲交叉设计,在左颞顶叶皮层接受5天的活性rTMS和5天的假rTMS(每天2000次刺激,强度为运动阈值的90%)。两周的刺激之间有1周的洗脱期。 结果:5天的活性rTMS使幻听显著改善(56%),而假刺激后未观察到变化。7名患者对活性治疗有反应,其中5名患者至少维持改善2个月。 结论:与假刺激相比,这些数据证实了低频rTMS应用于左颞顶叶皮层在减少难治性幻听方面的有效性。仅在5天内即可获得这种改善,且无严重的初始不良事件。

相似文献

[1]
Slow transcranial magnetic stimulation can rapidly reduce resistant auditory hallucinations in schizophrenia.

Biol Psychiatry. 2005-1-15

[2]
Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample.

Biol Psychiatry. 2005-7-15

[3]
Functional connectivity of the temporo-parietal region in schizophrenia: effects of rTMS treatment of auditory hallucinations.

J Psychiatr Res. 2010-2-26

[4]
Can low-frequency repetitive transcranial magnetic stimulation really relieve medication-resistant auditory verbal hallucinations? Negative results from a large randomized controlled trial.

Biol Psychiatry. 2010-12-7

[5]
A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations.

Psychol Med. 2009-8-6

[6]
Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations.

Arch Gen Psychiatry. 2003-1

[7]
Effect of augmentatory repetitive transcranial magnetic stimulation on auditory hallucinations in schizophrenia: randomized controlled study.

Aust N Z J Psychiatry. 2009-4

[8]
A preliminary fMRI study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rTMS.

Psychiatry Res. 2007-5-15

[9]
[The use of repetitive transcranial magnetic stimulation (rTMS) in auditory verbal hallucinations (AVH)].

Fortschr Neurol Psychiatr. 2010-11

[10]
A pilot double-blind sham-controlled trial of repetitive transcranial magnetic stimulation for patients with refractory schizophrenia treated with clozapine.

Psychiatry Res. 2010-12-24

引用本文的文献

[1]
Unravelling the genetic and molecular basis of low-frequency rTMS induced changes in functional connectivity density in schizophrenia patients with auditory verbal hallucinations.

Transl Psychiatry. 2025-7-10

[2]
Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia.

Front Psychiatry. 2025-4-15

[3]
Shaping tomorrow: how the STEP training course pioneered noninvasive brain stimulation training for psychiatry in France.

Front Psychiatry. 2024-11-25

[4]
Non-invasive brain stimulation for treatment-resistant schizophrenia: protocol of a systematic review and network meta-analysis.

Syst Rev. 2024-6-24

[5]
The efficacy of low frequency repetitive transcial magnetic stimulation for treating auditory verbal hallucinations in schizophrenia: Insights from functional gradient analyses.

Heliyon. 2024-4-24

[6]
Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.

Hum Brain Mapp. 2024-2-15

[7]
Protective Effects of Repetitive Transcranial Magnetic Stimulation Against Streptozotocin-Induced Alzheimer's Disease.

Mol Neurobiol. 2024-3

[8]
Cerebral blood flow changes in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.

Eur Arch Psychiatry Clin Neurosci. 2023-12

[9]
The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.

Front Psychiatry. 2023-1-25

[10]
Twice daily low frequency rTMS for treatment-resistant auditory hallucinations.

Int J Clin Health Psychol. 2023

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