过氧化物酶体增殖物激活受体γ配体与缺血再灌注损伤
Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury.
作者信息
Cuzzocrea Salvatore
机构信息
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, via C. Valeria, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy.
出版信息
Vascul Pharmacol. 2004 Jul;41(6):187-95. doi: 10.1016/j.vph.2004.10.004.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. PPAR-gamma has recently been implicated as a regulator of cellular proliferation and inflammatory responses. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review.
过氧化物酶体增殖物激活受体（PPARs）是核激素受体超家族中配体激活转录因子的成员，与视黄酸、类固醇和甲状腺激素受体相关。PPAR亚家族由三个成员组成，即PPAR-α、PPAR-β和PPAR-γ。最近有研究表明PPAR-γ是细胞增殖和炎症反应的调节因子。有充分证据表明，PPAR-γ的配体，包括某些噻唑烷二酮类药物，可减轻与缺血再灌注相关的组织损伤。本文将讨论PPAR-γ配体在缺血再灌注中的潜在应用。
Zotero 插件