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过氧化物酶体增殖物激活受体与急性肺损伤

Peroxisome proliferator-activated receptors and acute lung injury.

作者信息

Cuzzocrea Salvatore

机构信息

Dipartment Clinical and Experimental Medicine and Pharmacology, Centro per lo Studio ed il Trattamento dei Neurolesi Lungodegenti, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, 98123 Messina, Italy.

出版信息

Curr Opin Pharmacol. 2006 Jun;6(3):263-70. doi: 10.1016/j.coph.2006.01.008. Epub 2006 Mar 31.

DOI:10.1016/j.coph.2006.01.008
PMID:16580256
Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises three members: PPAR-alpha, PPAR-beta and PPAR-gamma. PPARs have recently been implicated as regulators of cellular proliferation and inflammatory responses. Furthermore, it has been demonstrated that PPAR-gamma and PPAR-alpha reduce lung injury associated with inflammation and shock.

摘要

过氧化物酶体增殖物激活受体（PPARs）是核激素受体超家族中配体激活转录因子的成员，与视黄酸、类固醇和甲状腺激素受体相关。PPAR亚家族包括三个成员：PPAR-α、PPAR-β和PPAR-γ。最近有研究表明PPARs是细胞增殖和炎症反应的调节因子。此外，已有研究证明PPAR-γ和PPAR-α可减轻与炎症和休克相关的肺损伤。

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