Masenga Sepiso K, Desta Selam, Hatcher Mark, Kirabo Annet, Lee Dexter L
HAND Research Group, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Zambia.
Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Curr Res Physiol. 2024 Nov 14;8:100133. doi: 10.1016/j.crphys.2024.100133. eCollection 2025.
Chronic kidney disease (CKD) is a major risk factor for death in adults. Inflammation plays a role in the pathogenesis of CKD, but the mechanisms are poorly understood. Peroxisome proliferator-activated receptor alpha (PPAR-α) is a nuclear receptor and one of the three members (PPARα, PPARβ/δ, and PPARγ) of the PPARs that plays an important role in ameliorating pathological processes that accelerate acute and chronic kidney disease. Although other PPARs members are well studied, the role of PPAR-α is not well described and its role in inflammation-mediated chronic disease is not clear. Herein, we review the role of PPAR-α in chronic kidney disease with implications for the immune system.
慢性肾脏病（CKD）是成人死亡的主要危险因素。炎症在CKD的发病机制中起作用，但其机制尚不清楚。过氧化物酶体增殖物激活受体α（PPAR-α）是一种核受体，也是过氧化物酶体增殖物激活受体（PPARs）的三个成员（PPARα、PPARβ/δ和PPARγ）之一，在改善加速急性和慢性肾脏病的病理过程中起重要作用。尽管其他PPARs成员已得到充分研究，但PPAR-α的作用尚未得到充分描述，其在炎症介导的慢性疾病中的作用也不清楚。在此，我们综述PPAR-α在慢性肾脏病中的作用及其对免疫系统的影响。
