Iconomopoulou S M, Andreopoulou A K, Soto A, Kallitsis J K, Voyiatzis G A
Foundation for Research and Technology-Hellas (FORTH) Institute of Chemical Engineering and High Temperature Chemical Processes (ICE/HT), P.O. Box 1414, GR-265 04 Rio-Patras, Greece.
J Control Release. 2005 Jan 20;102(1):223-33. doi: 10.1016/j.jconrel.2004.10.006.
Triclosan and phosphonium salt biocides have been separately incorporated into polystyrene-divinylbenzene (PS-DVB) beads by suspension polymerization. Ultraviolet (UV) absorption measurements have been used to monitor the release of these low molecular weight biocides out of the PS-DVB beads immersed in water-ethanol mixtures and in physiological saline. The release of the biocide agents is strongly dependent on either the DVB or/and the antimicrobial composition ratio in the beads. An increase of biocide incorporation in the PS/DVB beads was accompanied by a corresponding enhancement of its concentration in liquid mixtures. On the contrary, higher cross-linking densities hindered the biocide migration out of the beads by diminishing its release rate into either the aqueous ethanol solutions or the natural serum. Moreover, Fourier transform Raman (FT-Raman) spectra and Attenuated Total Reflectance Infrared (ATR-FTIR) measurements of the PS-DVB-Triclosan and PS-DVB-phosphonium salt beads, before and after their immersion in water-ethanol solutions, gave a similar qualitative evidence of the biocide release.
通过悬浮聚合将三氯生和鏻盐杀菌剂分别掺入聚苯乙烯 - 二乙烯基苯（PS - DVB）珠粒中。已使用紫外（UV）吸收测量来监测这些低分子量杀菌剂从浸入水 - 乙醇混合物和生理盐水中的PS - DVB珠粒中的释放情况。杀菌剂的释放强烈依赖于珠粒中的二乙烯基苯或/和抗菌剂组成比例。PS / DVB珠粒中杀菌剂掺入量的增加伴随着其在液体混合物中浓度的相应提高。相反，较高的交联密度通过降低其向乙醇水溶液或天然血清中的释放速率，阻碍了杀菌剂从珠粒中迁移出来。此外，对浸入水 - 乙醇溶液前后的PS - DVB - 三氯生和PS - DVB - 鏻盐珠粒进行傅里叶变换拉曼（FT - Raman）光谱和衰减全反射红外（ATR - FTIR）测量，给出了杀菌剂释放的类似定性证据。
